ISSN: 1859 - 2872
Primary mucoepidermoid carcinoma of the thyroid gland - misdiagnosed as metastatic adenocarcinoma to the thyroid
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Thyroid primary mucoepidermoid carcinoma is a malignant tumor classified as a salivary gland-type carcinoma of the thyroid. This type of tumor is extremely rare, with only a dozen cases reported to date, and has a high incidence in females. Due to its rarity, misdiagnosis can occur in clinical practice. We report a case of a female patient who presented with a thyroid nodule and vague clinical symptoms. Histologically, the tumor was characterized by intermediate and epidermoid (squamous) tumor cells with mucin-forming cystic and solid components. Despite immunohistochemical staining showing tumor cells positive for TTF1, Napsin A, Thyroglobulin, PAX8, CK19, p63, and negative for CK20, the initial conclusion still required differential diagnosis from metastatic adenocarcinoma to the thyroid. After cancer screening and consultation, the patient was confirmed to have a primary mucoepidermoid carcinoma of the thyroid. This case report and literature review provide additional information about the disease, definitive diagnosis, and treatment to improve the diagnostic capabilities and management of this patient group.
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