ISSN: 1859 - 2872
The role of the quantitative method in the assessment of hepatocellular carcinoma wash-in and wash-out phases by contrast enhanced ultrasound
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Objective: To quantitative analysis the wash-in and wash-out of hepatocellular carcinoma (HCC) by contrast enhanced ultrasound and to find out the correlation between these characterizations with tumor size and tumor differentiations. Subject and method: This study included 134 patients with 134 HCC nodules confirmed by histopathology from February 2014 to May 2017. All patients were evaluated by contrast enhanced ultrasound with contrast agent SonoVue (Bracco Company, Netherlands), using US machine (Philips EPIQ 5G, US) that has contrast programe including contrast auto-tracking software ROI, following the Guideline of WFUMB and EFSUMB 2012. Result: There were undifferentiated between HCCs with level’s size (< 20mm, 20 - < 40mm, ≥ 40mm), the well-differentiated HCCs and the moderately to poorly HCCs from time to peak (TP) and enhancement slope (ES). However, there were differentiated between HCCs with level’s size (< 20mm, 20 – < 40mm, ≥ 40mm), the well-differentiated HCCs and the moderately to poorly HCCs from wash-out time and clearance slope with statistically significant (p<0.05). Conclusion: The HCCs nodules showed a “fast-in” in the artery phase and “fast-out” in the portal and late phase. The wash-out time and clearance slope correlate with HCCs’s size and play an important role in predicting the differentiation of HCCs.
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