Drug-associated bullous pemphigoid with combination antihypertensive drug tolucombi (telmisartan and hydrochlorothiazide): A case report

  • Luu Ngoc Vi 108 Military Central Hospital
  • Nguyen Thi Quynh Trang 108 Military Central Hospital
  • Phung Thi Lan Huong 108 Military Central Hospital
  • Nguyen Thanh Ha 108 Military Central Hospital

Main Article Content

Keywords

Bullous pemphigoid, drug-associative bullous pemphigoid, combination antihypertensive drug tolucombi (telmisartan and hydrochlorothiazide)

Abstract

Bullous pemphigoid is an autoimmune subepidermal blistering disease, chronic progression and occurs primarily skin, mucosal invovelment is not frequent. This condition is more common in the elderly with a male and female ratio of 1:1. Drug-associative bullous pemphigoid (DABP) is a term used to describe instances of bullous pemphigoid demonstrating clinical, histological, or immunopathological features identical or similar to those of the idiopathic form of bullous pemphigoid, related to the systemic ingestion, or topical application. We report a case of a female patient with acute and multiform lesions: Erythema, vesicles, bullous, and fever after taking an antihypertensive drug containing telmisartan and hydrochlorothiazide. Basing on clinical features, histopathology and direct immunofluorescence we confirmed the diagnosis

Article Details

References

1. Trần Hậu Khang (2017) Bệnh học da liễu, tập 1. Nhà xuất bản Y học.
2. Schiavo AL et al (2013) Bullous pemphigoid: Etiology, pathogenesis, and inducing factors: Facts and controversies. Clin Dermatol 31(4): 391-399.
3. Warner C et al (2014) Bullous pemphigoid induced by hydrochlorothiazide therapy. J Drugs Dermatol 13(3): 360-362.
4. Cozzanin E et al (2015) Atypical presentations of bullous pemphigoid: Clinical and immunopathological aspects. Autoimmun Rev 14(5): 438-445.
5. Moro F, Fania L, Sinagra JLM (2020) Bullous pemphigoid: Trigger and predisposing factors. Biomolecules 10(10): 1432.
6. Verheyden MJ, Bilgic A, Murrell DF (2020) A systematic review of drug-induced pemphigoid. Acta Derm Venereol 100(15).
7. García Sanchez VC et al (2013) Hydrochlorothiazide induced bullous pemphigoid. Semergen 39(4): 214-217.