ISSN: 1859 - 2872
The study of treatment and prevention of aspirin combination with cilostazol in patients with acute ischemic stroke
Main Article Content
Keywords
Abstract
Objective: To evaluate effectiveness of treatment and prevention of aspirin combination with cilostazol in patients with noncardioembolic acute ischemic stroke. Subject and method: 102 patients with acute mild to moderate ischemic stroke (first 72 hours) hopitalized for inpatient treatment at Phu Tho General Hospital from September 2015 to October 2018. Result and conclusion: The proportion of male patients was 60.8%, higher than female ones, the median age of subjects in this study was 67 ± 8.4 years. After 6 months, there were more than 90% improvement in the NIHSS score, there were improvement in the mRS (mRS decreased by ≥ 1 point) after 6 months, study group had rates of improvement 90.5% higher than control group (62.7%), regarding the change in degree of stenosis and occlusion intracranial arteries, study group had rate of regressive stenosis 82.6% higher than control group (22.6%), the rate of extracranial carotid degressive stenosis in study group (39.2%) more than control group (2.6%); the rate of recurrence stroke in 6 months was 18.3% in control group and 4.8% in study group.
Article Details
References
2. Nguyễn Huy Ngọc (2012) Nghiên cứu đặc điểm lâm sàng cận lâm sàng và một số yếu tố nguy cơ ở bệnh nhân nhồi máu não tại Bệnh viện Đa khoa tỉnh Phú Thọ. Luận án Tiến sĩ.
3. Lê Đình Toàn (2016) Nghiên cứu đặc điểm lâm sàng, hình ảnh hẹp, tắc động mạch ở bệnh nhân nhồi máu động mạch não giữa trên phim chụp cộng hưởng từ mạch 3 Tesla. Luận án Tiến sỹ, Viện Nghiên cứu Khoa học Y Dược lâm sàng 108.
4. Chi NF, Wen CP, Liu CH et al, Taiwan Stroke Registry Investigators (2018) Comparison between aspirin and clopidogrel in secondary stroke prevention based on real‐world data. J Am Heart Assoc 7(19):e009856.
5. Katakami N, Kim YS, Kawamori R et al (2010) The phosphodiesterase inhibitor cilostazol induces regression of carotid atherosclerosis in subjects with type 2 diabetes mellitus: Principal results of the Diabetic Atherosclerosis Prevention by Cilostazol (DAPC) study: A randomized trial. Circulation 121(23): 2584-2591.
6. Lee YS, Kang DW, Lee SH et al (2011) Cilostazol in acute ischemic stroke treatment (CAIST trial): Arandomized double-blind non-inferiority trial. Cerebrovasc Dis 32: 65-71.
8. Sacco RL, Kasner SE, Broderick JP, et al; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism (2013) An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 44: 2064-2089.
9. Aoki J, Iguchi Y, Urabe T et al, ADS Investigators (2019) Acute aspirin plus cilostazol dual therapy for noncardioembolic stroke patients within 48 hours of symptom onset. J Am Heart Assoc 8(15):e012652.
10. Nakamura T, Tsuruta S, Uchiyama S (2012) Cilostazol combined with aspirin prevents early neurological deterioration in patients with acute ischemic stroke: A pilot study. Journal of the Neurological Sciences 313: 22-26.
11. Uchiyama S, Sakai N, Toi S et al, CATHARSIS Study Group (2015) Final results of cilostazol-aspirin therapy against recurrent stroke with intracranial artery stenosis (CATHARSIS). Cerebrovasc Dis Extra 5: 1-13.
Article Sidebar
