Xác định nồng độ kẽm, đồng, canxi trong huyết thanh và mối liên quan với lâm sàng ở bệnh nhân vảy nến mụn mủ toàn thân

Abstract

Objective: To evaluate serum zinc, copper, and calcium levels in patients with generalized pustular psoriasis. To determine the relevance between these substance levels in the blood and some clinical features in generalized pustular psoriasis patients. Subject and method: 49 patients with generalized pustular psoriasis examined at the Central Dermatology Hospital from 07/2019 to 04/2020 and 49 healthy control groups with a ratio of 1:1 in terms of age and gender. A descriptive, cross-sectional, controlled study. Result: The serum zinc was 0.85 ± 0.27mg/l which was significantly lower than the control group (p<0.001). The serum copper was 1.32 ± 0.26mg/l so there was a significant increase compared to the control group (p<0.001). The serum calcium with the value 109.49 ± 11.15mg/l did not differ from the control group (p>0.05). There was no relationship between the levels of serum zinc, copper, and calcium with age, gender, the duration of illness, and the disease severity of patients with generalized pustular psoriasis. Conclusion: In patients with generalized pustular psoriasis, there was a decrease of serum zinc level, an increase of serum copper level, and an insignificant decrease of serum calcium level. No association between these serum levels and clinical factors including age, gender, duration of illness, and severity of the disease was observed.