IL-17 serum in patients with chronic spontaneous urticaria at Hospital of Dermato-Venereology, Ho Chi Minh City

  • Tro Chau Van Trường Đại học Y khoa Phạm Ngọc Thạch
  • Thanh Do Thi Tuyet Bệnh viện Da liễu - Thành phố Hồ Chí Minh
  • Hao Nguyen Trong Bệnh viện Da liễu - Thành phố Hồ Chí Minh
  • Bac Pham Van Khoa Y - Đại học Quốc gia Hồ Chí Minh

Main Article Content

Keywords

Chronic spontaneous urticaria, IL-17 interleukin

Abstract

Objective: To determine serum concentrations of IL-17 and its associated factors in chronic spontaneous urticaria (CSU) patients. Subject and method: Case series report, ninety patients with chronic urticaria were enrolled into this study from December 2018 to August 2019. Determination of serum IL-17 was performed by means of ELISA (Enzyme Linked Immuno Sorbet Assay), using Human IL-17A ELISA Kit from ANOGEN company, Ontario, Canada. Code EL10053. Severity of disease was evaluated by Urticaria Activity Score 7 (UAS7) in a one-week period for every patient. For statistical analysis we used SPSS ver. 20.0 software. Result: The serum levels of IL-17 (mean ± SE) were 11.07 ± 19.26pg/mL. IL-17 level was higher in CSU patients with angiodema (5.28pg/mL) compared with those without angiodema (3.02pg/mL). This difference was statistically significant (p=0.006). IL-17 serum concentration was significantly higher in severe CSU patients as compared with mild CSU patients (4.72 vs 2.17pg/mL, p=0.036). Conclusion: Serum IL-17 levels were highly elevated in patients with chronic urticaria. It has been suggested that IL-17 may play an important role in chronic urticaria pathophysiology. Elevated serum concentration of IL-17 could be also used as a predictor of disease’s severity.

Article Details

References

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Published
Jan 15, 2020
Issue
Volume 15 - No 1/2020
Section
Articles
How to Cite
Chau VanT., Do Thi Tuyet T., Nguyen TrongH., & Pham VanB. (2020). IL-17 serum in patients with chronic spontaneous urticaria at Hospital of Dermato-Venereology, Ho Chi Minh City. Tạp Chí Y Dược lâm sàng 108, 15(1). Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/9