ISSN: 1859 - 2872
Study on 18F-FLT production for PET/CT
Main Article Content
Keywords
18F-FLT, module, LLC lung cancer, PET/CT
Abstract
Objective: To evaluate the applicability of 18F-FLT production and 18F-FLT PET/CT imaging in Vietnam. Subject and method: 18F-FLT radiopharmaceutical was prepared on the self-developed module of the 108 Military Central Hospital. The product quality was according to Ph. Eur. 14. To compare the 18F-FDG PET and 18F-FLT PET imaging on BALB/c mice model caused LLC lineage secondary lung cancer. Result: The 18F-FLT radioactivity per batch ranged from 57 ± 4 to 184 ± 14mCi depend on 18O water bombardment time, the yields (EOS) ranged from 9.6 ± 1.3 đến 27.6 ± 2.1%, however, the highest yield was achieved with 20 minutes bombardment. Both 18F-FDG and 18F-FLT were increased uptake in the tumor. The difference is that 18F-FDG was increased uptake in the brain, but 18F-FLT was not because 18F-FLT almost does not cross the blood-brain barrier. Conclusion: Production of 18F-FLT for PET/CT imaging in Vietnam is feasible.
Article Details
References
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2. Berman DS, Hachamovitch R, Kiat H, Cohen I, Cabico JA, Wang FP, Friedman JD, Germano G, Van Train K, and Diamond GA (1995) Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: Abasis for optimal utilization of exercise technetium-99msestamibi myocardial perfusionsingle-photon emission computed tomography. Journal of the American College of Cardiology 26(3): 639-647.
3. Kostakoglu L, Agress H and Goldsmith SJ (2003) Clinical Role of FDG PET in evaluation of cancer patients. Radiographics 23: 315-340.
4. Lee Y (2010) Radiopharmaceuticals for Molecular Imaging. The Open NuclearMedicineJournal 2: 178-185.
5. Grierson JR and Shields AF (2000) Radiosynthesis of 3’-Deoxy-3'-[(18)F]Fluorothymidine: [(18)F]FLT for imaging of cellular proliferation in vivo. NuclearMedicine and Biology 27: 143-156.
6. Been LB, Suurmeijer AJ, Cobben DC, Jager PL, Hoekstra HJ and Elsinga PH (2004) [18F]FLT-PET in incology: Current status and opportunities. European Journal of Nuclear Medicine and Molecular Imaging 31: 1659-1672.
7. Fuchs K et al (2013) In vivo imaging of cell proliferation enables the detection of theextent of experimental rheumatoid arthritis by 3’-Deoxy-3’-18F-Fluorothymidine and small-animal PET. Journal of Nuclear Medicine 54: 151-158.
8. Wilson IK, Chatterjee S and Wolf W (1991) Synthesis of 3’-Fluoro-3’-Deoxythymidineand studies of Its 18F-radiolabeling, as a tracer for the non-Invasive monitoring of the biodistribution of drugs against AIDS. Journal of Fluorine Chemistry 55: 283-289.
9. Nguyễn Khắc Thất, Nguyễn Thị Kim Dung, Mai Hồng Sơn, Lê Ngọc Hà (2021) Đánh giá hình ảnh phân bố dược chất phóng xạ 18F-fluorine fluorothymidine PET trên động vật thực nghiệm. Tạp chí Y Dược học số 25 - Tháng 07/2021, tr. 46-50.
10. Bùi Thanh Rin, Nguyễn Khắc Thất, Trần Văn Diện, Trương Thành Đạt, Nguyễn Đức Trung, Nguyễn Văn dinh, Phạm Tuấn Linh (2021) Nghiên cứu điều chế dược chất phóng xạ 18F-fluorothymidine trên module tự động được phát triển trong nước. Tạp chí Y Dược học số 25 - Tháng 7/2021, tr. 117-122.
11. ICH (2013) The international conference on harmonisation of technical requirements for registration of pharmaceuticals for human use.
12. Strickley RG (2004) Solubilizing excipients in oral and injectable formulations. Pharmaceutical Research 21: 201-230.
13. Scott PJH and Hockley BG (2012) Radiochemical syntheses, volume 1: Radiopharmaceuticals for positron emission tomography. John Wiley and Sons, Hoboken.
14. Serdons K, Verbruggen A and Bormans G (2008) The presence of ethanol inradiopharmaceutical injections. Journal of Nuclear Medicine 49: 2071.
15. Patrice M, Ali O, Michel P, Jacky S, Patrice
L, Fr´ed´eric Boisson, David B (2016) Automated and efficient radiosynthesis of [18F]FLT using a low amount of precursor. Nuclear Medicine and Biology
doi: 10.1016/j.nucmedbio.2016.05.009.
16. Leonardo Tafas C. Nascimento, Juliana B Silva, Marina B Silveira, Priscilla F Santos, and Tiago Faria (2013) Synthesis and quality control of [F]fluorothymidine. 2013 International Nuclear Atlantic Conference - INAC 2013, Recife, PE, Brazil: 24-29.
17. Leonardo TCN, Marina BS, Soraya MZMD Ferreira, Juliana BS ( ) Comparison between two ethanolic solutions for 3’-Deoxy-3’-[18F]Fluorothymidine elution.
18. Herholz K, Rudolf J & Heiss WD (1992) FDG transport and phosphorylation in human gliomas measured with dynamic PET. Journal of Neuro-Oncology 12: 159-165.
19. Shields AF et al (1998) Carbon-11-thymidine and FDG to measure therapy response. Journal of Nuclear Medicine 39(10): 1757-1762.
20. Kong XB et al (1992) Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3’-fluoro-3’- deoxythymidine and 3’-azido-3’-deoxythymidine. Antimicrob Agents Chemotherapy 36: 808-818.
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Published
Nov 9, 2021
Section
Articles
How to Cite
ThatN. K., Đức Trung N., Thanh RinB., Văn DiệnT., Thi Kim DungN., Hong SonM., Tuan LinhP., Quang KhaiB., Nguyen BinhD., Huy CanhN., Tuan VoD., & Trong TungH. (2021). Study on 18F-FLT production for PET/CT. Tạp Chí Y Dược lâm sàng 108, 16(DB11). https://doi.org/10.52389/ydls.v0i0.884