Nghiên cứu đặc điểm sử dụng thuốc hạ huyết áp và hạ đường máu ở bệnh nhân tăng huyết áp có kèm đái tháo đường typ 2

Abstract

Objective: To characteristic drug use to treat hypertension and type 2 diabetes. To evaluate the effects of blood pressure coltrol in hypertensive patients with typ 2 diabetes mellitus at Treatment Institute of Senior Officer - 108 Military Central Hospital. Subject and method: Retrospective observational methods was conducted in 426 patients, those who were diagnosed of hypertension and diabetes disease with inpatient care at the Treatment Institute of Senior Officer - 108 Military Central Hospital from Aug 2019 to Dec 2020. Result: All antihypertensive drugs in the research were in the antihypertensive list recommended by Vietnamese Society of Cardiology. Renin - angiotensin - aldosterone system inhibition and calcium channel inhibitors drug were the two most popular drug groups (65.8% and 37.1% respectively). 58.5% patients were treated following the multi-therapy regimen, in which 17.6% patient had been used both of the Renin-angiotensin-aldosterone system inhibition and calcium channel inhibitors drugs. In treatming drugs for diabetes, biguanid and insulin were the two most popular drug groups (57.3% and 44.8%, respectively). The rate of using multi-therapy regimens was higher than the rate of using uni-therapy regimens (64.7% > 35.3%), in which 10.9% patient had been used both of the sulphunylerea and biguanid drugs. There were relatively large number of interactions between antihypertensive and antidiabetic drugs (average 2.4 interaction per 1 prescription and 73.4% of prescriptions have interactions), however the interaction were moderate, not clinically. Additionally, those who had achieved the target blood pressure were 97.3%. Conclusion: The rate of using multitherapy regimens was higher than the rate of using uni-therapy regimens, the interactions between antihypertensive and antidiabetic drugs were relatively large number; most patients were evaluated as having good prognosis after treatment.