Phân tích tình hình sử dụng kháng sinh dự phòng trên bệnh nhân phẫu thuật tại Bệnh viện Hữu nghị

Abstract

Objective: To evaluate the appropriate use of antibiotics before and after issuance of local antimicrobial surgical prophylaxis guideline. Subject and method: A before-after study was conducted in patients with clean or clean-contaminated surgery in Friendship Hospital, which compared surgical prophylaxis antibiotic use before and after the issuance of local guideline. The criteria which were compared between two periods included: Indication, choice, dosing, time of administration, redosing, duration, overall appropriateness. Result: Totally 82 surgeries were enrolled, of which 100% of patients classified as clean or clean-contaminated surgery were prescribed surgical prophylaxis antibiotics. After issuing guideline, the proportion of appropriate antibiotic choice, time of administration and dosing regimen had increased significantly (p<0.05). However, the duration of antibiotic use was still prolonged, with median of 7 days in both periods. The percentages of adherence to all criteria before and after guideline issuance were 2.4% and 24.3% (p<0.05), respectively. None of the patients in both periods were diagnosed with surgical site infections. Conclusion: The study showed that the proportion of appropriate prophylactic antibiotic use improved significantly after local guideline was issued, specifically with antimicrobial choice, dosing and time of administration criteria. In addition, duration of antimicrobial use was still prolonged, indicating that more strategies would be implemented to effectively managing antibiotics use in surgery patients at the hospital.