ISSN: 1859 - 2872
The real situation of using antimicrobials in treatment for Gram-negative bacteremia at 108 Military Central Hospital in 2020
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Abstract
Objective: To describe antimicrobial susceptibility pattern and antibiotic regimens among patients with Gram-negative bacteremia at 108 Military Central Hospital in 2020. Subject and method: A retrospective cohort study used data from electronic medical records of patients with blood cultures positive for Gram-negative bacteria in 2020. Result: 155 patients were included in the study. The most common pathogens were E. coli (47.1%), K. pneumoniae (28.7%). The rate of MDR, XDR and PDR were 56.7%, 15.9% and 2.5%; respectively. The high rate of using empiric therapy based on BL/BLI or carbapenem was accorded with the high percentage of multi-resistant bacteria (over 70%). Fluoroquinolone was the most common antibiotic chosen in the empiric and definite combination regimens, while the rate of sensitive bacteria with this antibiotic group was quite low (less than 50%). The proportion of patients with isolated pathogens susceptible to empirical and definitive therapy were 51.0% and 63.1%, respectively. Conclusion: The study has shown several outstanding clinical and microbiology characteristics as well as the pattern of antibiotic use in patients with Gram-negative bacteremia. This will be very important to develop several guidelines for the management of sepsis as well as carrying out relevant clinical pharmacy activities.
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References
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