Prevalence of adverse drug reactions (ADRs) on ADR management software at 108 Military Central Hospital

  • Duong Kieu Oanh 108 Military Central Hospital
  • Le Thi My 108 Military Central Hospital
  • Le Minh Hong 108 Military Central Hospital
  • Ngo Thi Xuan Thu 108 Military Central Hospital
  • Nguyen Thanh Hai Hanoi University of Pharmacy

Main Article Content

Keywords

ADR report, ADR, ADR report management software

Abstract

Objective: To survey the adverse drug reactions (ADRs) on ADR reporting management software at 108 Military Central Hospital. Subject and method: All ADR reports are being managed on Power BI software at the Department of Pharmacy of 108 Military Central Hospital from January 1, 2019 to September 30, 2021. A retrospective descriptive study. Result: In 539 ADR reports, 696 ADRs were suspected to be drug-induced (1.29 ADR per report). The majority of ADR reports were made by pharmacists (55.8%) and doctors (42.1%). The most ADRs were moderate (50.4%) and mild (35.8%) ADRs. The ADRs was severe (13.2%) and fatal (0.6%). Some drugs often cause severe ADR such as: Rituximab (1.15%), cefuroxime (1.01%), cyclophosphamide (0.72%), iohexol (0.57%), cisplatin (0.57%), mesna (0.57%). After ADR management, 93.9% of patients recovered, a small proportion of patients did not recover (5.7%) or died (0.4%). Conclusion: This study described the ADR based on ADR reports from January 1, 2019 to September 30, 2021 at 108 Military Central Hospital.

Article Details

References

1. Bộ Y tế (2021) Hướng dẫn Quốc Gia về Cảnh giác dược. Quyết định số 122/QĐ-BYT, ngày 11/01/2021.
2. Nguyễn Tấn Sĩ (2008) Khảo sát tình hình ADR và công tác báo cáo ADR tại Bệnh viện C Đà nẵng. Báo cáo tốt nghiệp chuyên khoa cấp 1, Trường Đại học Y Dược Thành phố Hồ Chí Minh.
3. Đỗ Ngọc Trâm (2013) Khảo sát tình hình báo cáo phản ứng có hại của thuốc (ADR) tại Bệnh viện Bạch Mai giai đoạn 2011-2012. Khóa luận tốt nghiệp dược sĩ, Trường Đại học Dược Hà Nội.
4. Alexopoulou A, Dourakis SP, Mantzoukis D, Pitsariotis T, Kandyli A, Deutsch M et al (2008) Adverse drug reactions as a cause of hospital admissions: A 6‐month experience in a single center in Greece. Eur J Intern Med 19: 505-510.
5. Claudia G, Paola MC, Eleonora M, Giuseppina TR, Giuseppe M, Giorgio B, Franco R, Rosarita F, Edoardo S, Vincenzo A (2018) Adverse drug reactions in hospitalized patients: Results of the FORWARD (Facilitation of Reporting in Hospital Ward) study. Front. Pharmacol 11.
6. Khabbal Y, Alami L, Nejjari C (2012) Introduction of pharmacovigilance in a new university hospital in Morocco: How and why. East Mediterr Health J 18(6): 648-652.
7. Lazarou Lazarou J (1998) Incidence of adverse drug reactions in hospitalised: A meta-anylasis of prospective studies. Journal of Amerian Medical Association 279: 1200-1205.
8. Sze Ling Chan, Xiaohui Ang, Levana L Sani, Hong Yen Ng, Michael D Winther, Jian Jun Liu, Liam R Brunham, Alexandre Chan (2016) Prevalence and characteristics of adverse drug reactions at admission to hospital: a prospective observational study. Br J Clin Pharmacol 82(6): 1636-1646.