Tầm soát biến cố giảm bạch cầu trung tính liên quan đến vancomycin thông qua kết quả xét nghiệm huyết học tại Bệnh viện Bạch Mai

Abstract

Objective: To screen and identify vancomycin-induced neutropenia in hospitalized patients based on laboratory database and to describe characteristics of these case. Subject and method: This was a descriptive-restropective study of inpatients at Bach Mai Hospital. These patients had a neutrophil cout < 1.5G/L and used vancomycin based on laboratory database and electronic medical record were collected in 2019. The cases of vancomycin-induced neutropenia were defined according to the WHO-UMC causality assessment system. Result: Of 2248 neutropenia cases, 75 suspected vancomycin-induced neutropenia (3.3%) cases were identified. The incidence of vancomycin-induced neutropenia in patients treated with vancomycin was 75/2998 (2.5%) which corresponding to 75/165644 (0.05%) inpatients during the study period. The severity of neutropenia in most of the cases were classified as serious and life-threathening (57.4%), with lag time of more than 1 weeks (52.0%) and the time to be resolved within one week (54.7%). Conclusion: Screening laboratory test result were found to be adjunctive approach to identify cases suspected with vancomycin-induced neutropenia, which is often under-reporting by the spontaneous reporting system,.