Hiệu quả của can thiệp dược lâm sàng trong phòng tránh tương tác thuốc - thuốc bất lợi trên bệnh nhân điều trị ngoại trú tại Bệnh viện Đa khoa Xanh Pôn

Abstract

Objective: To evaluate the efficiency of clinical interventions on preventing contraindicated drug - drug interactions (cDDIs) among outpatients in Saint Paul General Hospital. Subject and method: This interventional study included all outpatients’ prescriptions from 1/1/2020 to 31/5/2021 (with the first intervention is to provide information on the detected cDDIs for prescribers; the second intervention is to educate prescribers about cDDIs and provide information on the detected cDDIs monthly). cDDIs were detected by Navicat^® software. Result: Before interventions (1/1/2020 - 30/9/2020), the prevelance of cDDIs was 0.053% with 5 detected pairs: Simvastatin-Clarithromycin (0.025%), clarithromycin-domperidon (0.013%), clarithromycin-alfuzosin (0.009%), gemfibrozil-simvastatin (0.003%), clarithromycin-Ivabradin (0.002%). There was a significant decrease in the prevelance of cDDIs to 0.024% with p<0.01 after the first intervention (1/10/2020 - 31/12/2020). After the second intervetion, no pairs of cDDIs occurred in prescribtions of outpatients. Conclusion: Clinical interventions were shown effectively in prevention of cDDIs.