Phân tích hoạt động duyệt phiếu yêu cầu sử dụng thuốc colistin trên bệnh nhân hồi sức tích cực tại Bệnh viện Trung ương Quân đội 108

Abstract

Objective: To analyse of clinical, microbiological and initial prescribing characteristics of patients who was used colistin in the intensive care unit at the 108 Military Central Hospital. To analyse of characteristics approving the order form for using colistin of clinical pharmacist. Subject and method: inpatients treated with colistin from February 26^th 2020 to May 17^th 2021 at 02 departments: The Intensive Care Center and Department of Air-borne infectious diseases and intensive care of 108 Military Central Hospital. Method: This was a prospective, observational study. Result: 116 patients were treated in group with OF and 16 in Non-OF. Three most common isolated species were A. baumannii, K. pneumoniae and P. aeruginosa. There were 96 DRPs detected and interfered in the drug approval process with the acceptable rate of 75.0%. The rate of occurrence of nephrotoxicity was 47.5%, in which was stage R - risk: 82.8%, stage I - injury: 17.2%. The rate of cure/relief was 54.8%, death rate: 45.2%. Conclusion: The patients in the intensive care units of the 108 Military Central Hospital were critical ill patients with a high rate of multidrug-resistant infections. The using order form’s colistin on this patient group helped to standardize and optimize the use of colistin through direct interventions when DRPs were detected by clinical pharmacists. Collaboration between doctors and clinical pharmacists contributes to the safety and effectiveness of colistin use in critically ill patients.