Preparation of 18F-fluoromethylcholine radiopharmaceutical by using homemade modular synthesizer

  • Vu Thanh Quang 108 Military Central Hospital
  • Ha Ngoc Khoan 108 Military Central Hospital
  • Bui Thanh Rin 108 Military Central Hospital
  • Nguyen Trung Dung 108 Military Central Hospital
  • Pham Tuan Linh 108 Military Central Hospital
  • Do Trang Manh Cuong Bệnh viện Trung ương Quân đội 108
  • Phan Viet Anh 108 Military Central Hospital
  • Nguyen Huu Duong 105 Military Hospital
  • Vu Huy Khoi Weapon Research Institute
  • Doan Thi Thu Hien Institute of Rare Radiation Technology

Main Article Content

Keywords

Automatic synthesizer, 18F-FCH radiopharmaceutical

Abstract

18F-fluoromethylcholine (18F-FCH) pharmaceuticals are used in positron emission tomography/computed tomography (PET/CT) imaging to diagnose prostate cancer and hepatocellular carcinoma. Currently, this radiopharmaceutical is not available in Vietnam. Objective: To prepare the 18F-FCH radiopharmaceuticals using a homemade automatic synthesizer. Subject and method: The 18F-FCH is formed through substitution reaction of 18F-fluorobromomethane (FBM) with the precursor of dimethylethanolamine (DMEA). This radiochemical process is carried out completely automatically on the homemade automatic synthesizer. Result: 18F-FCH radiopharmaceutical was prepared with radiochemical purity of more than 99.9% and having residual amounts of ethanol, ACN and DMEA were less than 5000µgr/ml, 400µg/ml and 100µg/ml respectively. Syntheses time of one batch of 18F-FCH was 38 ± 1 min, syntheses yield was 40.4 ± 0.4% with no decay correction. Conclusion: The 18F-FCH radiopharmaceutical has been successfully prepared on the homemade automatic synthesizer. The product 18F-FCH having pH, half-life, radiochemical purity and residual amounts of ethanol, ACN and DMEA meets the requirements of European Pharmacopoeia 2017.

Article Details

References

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Published
Sep 15, 2021
DOI: https://doi.org/10.52389/ydls.v16i6.854
Issue
Volume 16 - No 6/2021
Section
Articles
How to Cite
QuangV. T., KhoanH. N., RinB. T., DungN. T., LinhP. T., CuongD. T. M., AnhP. V., DuongN. H., KhoiV. H., & HienD. T. T. (2021). Preparation of 18F-fluoromethylcholine radiopharmaceutical by using homemade modular synthesizer. Tạp Chí Y Dược lâm sàng 108, 16(6). https://doi.org/10.52389/ydls.v16i6.854