ISSN: 1859 - 2872
Value of 18F-FDG PET/CT in intensity-modulated radiation therapy planning for upper third esophageal cancer patients
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Abstract
Objective: To determine the effect of 18F-FDG PET/CT in intensity-modulated radiation therapy planning and treatment outcomes for upper-third esophageal cancer patients. Subject and method: A prospective interventional study in 60 patients with upper third esophageal cancer who underwent definitive chemo-radiation with IMRT technique. Toxicities and treatment responses were evaluated. Result: The mean tumor volumes on 18F-FDG PET/CT and CT were 26.1 ± 15.2cm3 and 27.5 ± 15.2cm3 (p<0.05), the median lymph node volumes on 18F-FDG PET/CT and CT were 4.2cm3 and 1.5cm3 (p<0.05), respectively. 18F-FDG PET/CT altered tumor volume in 63.4% and lymph nodes volume in 75% of patients. The 4-year overall survival and loco-regional control rates were 48.6% and 41.8%. The rates of acute toxicities grade 3 and grade 4 were 20% and 3.3%, respectively. Conclusion: 18F-FDG PET/CT altered the radiation treatment target volumes significantly when compared to CT with favorable treatment outcomes. It should be applied routinely in the radiotherapy planning procedure for upper-third esophageal cancer.
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References
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