ISSN: 1859 - 2872
Diagnostic value of serum heart-type fatty acid-binding protein (H-FABP) levels in patients with ST-segment elevation myocardial infarction
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Abstract
Objective: To study the diagnostic value of H-FABP serum concentration in ST-segment elevation myocardial infarction (STEMI). Subject and method: A descriptive, cross-sectional study, 146 STEMI patients were admitted to 175 Military Hospital from 09/2017 to 06/2020 and 146 subjects in the control group, quantification of H-FABP at the admission time. Result: The diagnostic value of H-FABP in STEMI: AUC 0.945, sensitivity 88.4%, specificity 95.2%, cut-off point was 6.00ng/ml, the AUC and the sensitivity of H-FABP were lower than those of hs-TnT but the specificity was higher (95.2% vs 80.8%), AUC, sensitivity, specificity were higher than those of CK-MB. According to hospital admission time: Subjects admitted within 3 hours and over 3 - 6 hours after the onset of symptoms, H-FABP had the highest value in diagnosis with AUC of 0.956 and 0.979, respectively, higher than hs-TnT and CK-MB. Group of patients admitted over 6 to 12 hours and over 12 hours; diagnostic value of H-FABP gradually decreased with AUC 0.962 to 0.891, respectively; lower than hs-TnT, and CK-MB (> 12 hours group). Specificity of H-FABP was higher than Hs-TnT and CK-MB. Conclusion: H-FABP has high value in diagnosing STEMI, especially in subjects who were admitted to hospital before 6 hours. At later times, H-FABP may be possible to consider adding test with hs-TnT and CKMB due to its high specificity.
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References
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