ISSN: 1859 - 2872
Serum adiponectin and leptin levels of plaque psoriasis patients in Ho Chi Minh City Hospital of Dermatology and Venereology
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Abstract
Objective: To evaluate of serum adiponectin, leptin levels and related factors in plaque psoriasis patients and controls at Ho Chi Minh City Dermatology Hospital. Subject and method: 48 cases of plaque psoriasis and 48 healthy people at Ho Chi Minh City Dermatology Hospital. Plaque psoriasis is diagnosed based on clinical manifestation and severity is calculated based on PASI score. Adiponectin level was measured by immunoturbidimetric assay and leptin was measured by sandwich ELISA. Result: The median of serum adiponectin level in the patient group was 4.27 (2.68 - 6.38) μg/ml lower than which of the control group was 5.39 (3.66 - 7.98) μg/ml, p=0.036. In the female subgroup, the serum adiponectin level of the patient group was 5.44 (3.84 - 6.64) μg/ml, that was also lower than that of the control group which was 7.02 (4.83 - 10.4) μg/ml (p=0.016). There was no statistically significant difference in serum leptin level in the psoriatic group and the control group (p=0.985). Serum leptin level was related to PASI severtity. Conclusion: The serum adiponectin level in the patient group was statistically significant lower than the control group, in general and in the female subgroup. There was no difference in leptin concentration between the disease group and the control group. Serum leptin concentration of psoriatic patients was related to PASI severity.
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References
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