ISSN: 1859 - 2872
Serum TNF- levels in patients with vitiligo at Ho Chi Minh City Hospital of Dermato-Venereology
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Abstract
Objective: To compare serum TNF-a (Tumor necrosis factor alpha) levels between the patients and the controls. To identify the relationship between serum TNF-a and clinical characteristics. Subject and method: We performed a controlled cross-sectional study study in 51 patients with vitiligo and 51 age-and sex-matched healthy controls at Ho Chi Minh City Hospital of Dermato‐Venereology from January 2021 to June 2021. Result: The serum TNF-a levels of the patients were 10.84 ± 3.23pg/mL, significantly higher than those of healthy subjects 6.98 ± 1.88pg/mL (p<0.0001). Patients with progressive vitiligo have a higher serum level of TNF-α than those with stable vitiligo (p=0.001). Serum TNF-a levels were significantly higher in vitiligo patients with Koebner phenomenon than in patients without it (p=0.012). Patients age, age of onset, disease duration, affected body surface area, clinical features of lesions in patients with vitiligo were not found to be correlated to serum TNF-a. Conclusion: We found that serum TNF-a levels were significantly elevated in patients with vitiligo than in the healthy persons. This study demonstrates a relationship between serum TNF-a levels and disease activity, Koebner phenomenon.
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References
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