Nghiên cứu nồng độ đồng và tỉ số đồng/ceruloplasmin huyết thanh của bệnh nhân vảy nến mảng tại Bệnh viện Da liễu Thành phố Hồ Chí Minh

Abstract

Objective: To compare serum copper and copper to ceruloplasmin ratio between the patients and the controls. To identify the relationship between serum copper, copper to ceruloplasmin ratio and clinical characteristics. Subject and method: We designed a cross-sectional study with convenience sampling of 66 cases of psoriasis patients and 66 normal people at dermatology clinic of Ho Chi Minh City Hospital of Dermatology and Venereology during the period January 2021 to June 2021. Result: Mean age was 44 years old. 74.2% of the patients were male. 15% of the patients had family history of psoriasis. There was no significant difference in serum copper levels between the cases and the controls (mean 76.7µg/dL vs mean 75.4µg/dL, p=0.55). Serum ceruloplasmin levels were significantly raised among the cases as compared with the controls (mean 41.2mg/dL vs mean 32.7mg/dL, p=0.001). Serum copper to ceruloplasmin ratio were significantly low in the psoriasis group as compared with the controls (mean 2.1 vs mean 2.4, p=0.001). Females have higher levels of both serum copper and copper to ceruloplasmin ratio than males (p=0.017, p=0.039). The older the patients get, the higher levels of serum copper they have (p=0.036, r = 0.26). Patients who drink alcohol more than once a month had lower copper to ceruloplasmin ratio than those who do not drink (p=0.049). Conclusion: There is no difference in serum copper level between the controls and the patients. The patients have lower copper to ceruloplasmin ratio than the controls. Serum copper raise as the patients get older. Gender can affect serum copper level and copper to ceruloplasmin ratio in psoriasis patients. Copper to ceruloplasmin is found to be relative to alcohol consumption