Upgrading 18F-NaF radiopharmaceutical synthesis to scale production

  • That Nguyen Khac 108 Military Central Hospital
  • Dien Tran Van 108 Military Central Hospital
  • Rin Bui Thanh 108 Military Central Hospital
  • Dinh Nguyen Van 108 Military Central Hospital
  • Linh Pham Tuan 108 Military Central Hospital
  • Linh Nguyen Tran 108 Military Central Hospital

Main Article Content

Keywords

18F-NaF, important synthesis factors, 1000 ± 100mCi/batch

Abstract

Objective: To modulate a stable 18F-NaF at a production of 1000 ± 100mCi/batch. Subject and method: 18F-NaF, using a synthetic chemical process 18F-NaF at laboratory scale not exceeding 100mCi/batch. Synthesis formula: 1000 ± 100mCi 18F-NaF/15ml, NaCl 0.9%: 15ml; bombardment energy: 18MeV; Beam intensity 35 - 36.5µA, 30 minutes of bombardment; radioactive chemistry: NaCl 0.9%: 3ml; Water: 5ml; Synthesis time 15 minutes; adding 12ml of 0.9% NaCl to the final product vial. Investigating the appropriate bombardment time to produce 18F-NaF of 1000 ± 100mCi/batch and verifying critical process parameters for this procedure. Result: The radioactivity of 18F-NaF produced linear with a target shooting time of 15 to 30 minutes and with 30 minutes bombardment, it was possible to generate enough 1000 ± 100mCi of 18F-NaF to meet the goal of the study. Investigation of the critical parameters and the yield of 18F-NaF obtained showed that the 1000 ± 100mCi synthesis process was stable. Products of 3 consecutive batches met the main criteria according to the USP. Conclusion: Using the synthesis formula and specifications for the preparation of laboratory 18F-NaF not exceeding 100mCi/batch on a 30MeV cyclotron at 108 Military Central Hospital and 30 minutes of bombardment can produce 1000 ± 100mCi of 18F-NaF.

Article Details

References

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Published
Mar 8, 2021
DOI: https://doi.org/10.52389/ydls.v16i2.727
Issue
Volume 16 - No 2/2021
Section
Articles
How to Cite
Nguyen KhacT., Tran VanD., Bui Thanh R., Nguyen VanD., Pham TuanL., & Nguyen TranL. (2021). Upgrading 18F-NaF radiopharmaceutical synthesis to scale production. Tạp Chí Y Dược lâm sàng 108, 16(2). https://doi.org/10.52389/ydls.v16i2.727