ISSN: 1859 - 2872
Acute toxicity of 18F-NaF in mice
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Abstract
Objective: To evaluate the acute toxicity of 18F-NaF produced on self-manufactured module of Cyclotron Center at 108 Military Central Hospital. The experiments were conduced on Swiss white mice with 100 times of human dose according to the single-dose toxicity test method for the active ingredients at very small doses in the guidance of the European Pharmaceutical Administration (EMA), incorporating general principles in acute toxicity studies following OECD guidelines. Result: After 24 hours and 14 days of 17.1mCi/kg 18F-NaF injection, the weight, blood tests such as WBC, RBC, HGB, PLT, AST, ALT… of mices did not affect by the 18F-NaF and the histopathologic fearures of mices were not also affected by 18F-NaF. Conclusion: 18F-NaF radiopharmaceutical prepared by the self-manufactured module of Cyclotron Center at 108 Military Central Hospital had no acute toxicity in the mice model.
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References
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