ISSN: 1859 - 2872
Investigation of in vitro biodegradation and biocompatibility of hydroxyapatite coated Mg for biodegradable implant applications
Main Article Content
Keywords
Biodegradable magnesium implants, hydroxyapatite, biodegradation, biocompatibility
Abstract
Objective: To evaluate of the biodegradation rate and biocompatibility of HAp coated Mg for biodegradable implant applications. Subject and method: Biodegradable HAp coated Mg will be used for cell culture tests in MEM-a medium. The biodegradation rate was evaluated via the amount of hydrogen gas released and the morphology of the samples. The in vitro biocompatibility of the material was evaluated via proliferation of the cell and cell morphology. Result: The cell culture test using MC3T3-E1 cell line demonstrated that HAp improved both biocorrosion resistance and biocompatibility of the implant materials. Conclusion: The HAp coated Mg has moderate biodegradation rate and good biocompatibility and is suitable for implant applications.
Article Details
References
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2. Wu S, Liu X, Yeung KWK, Liu C, and Yang X (2014) Biomimetic porous scaffolds for bone tissue engineering. Mater. Sci. Eng. R Reports 80(1): 1-36.
3. Larry HL and Julia MP (2002) Third-generation biomedical materials. Science 80(295): 1014-1017.
4. Mordike BL and Ebert T (2001) Magnesium Properties - applications - potential. Materials Science and Engineering A 302(1):37-45.
5. Sumner DR (2015) Long-term implant fixation and stress-shielding in total hip replacement. J. Biomech 48(5): 797-800.
6. Witte F (2010) The history of biodegradable magnesium implants: A review. Acta Biomater 6(5): 1680-1692.
7. Atrens A, Liu M, and Zainal Abidin NI (2011) Corrosion mechanism applicable to biodegradable magnesium implants. Mater. Sci. Eng. B Solid-State Mater. Adv. Technol 176(20): 1609-1636.
8. Noviana D, Paramitha D, Ulum MF, and H Hermawan (2016) The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats. J. Orthop. Transl 5: 9-15.
9. Li X, Liu X, Wu S, Yeung KWK, Zheng Y, and Chu PK (2016) Design of magnesium alloys with controllable degradation for biomedical implants: From bulk to surface. Acta Biomater 45: 2-30.
10. Kim YK et al (2018) Gas formation and biological effects of biodegradable magnesium in a preclinical and clinical observation. Sci. Technol. Adv. Mater 19(1): 324–335.
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Published
Mar 31, 2021
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How to Cite
HanhL., HảiL. V., HoàngN. T., HảiL. M., TrangL. T., QuânL. V., & NamN. V. (2021). Investigation of in vitro biodegradation and biocompatibility of hydroxyapatite coated Mg for biodegradable implant applications . Tạp Chí Y Dược lâm sàng 108, 16(1). https://doi.org/10.52389/ydls.v16i1.696