Evaluating the effect of intraoperative navigated ultrasonography in intracranial tumor resection

  • Nguyễn Trọng Yên Bệnh viện Trung ương Quân đội 108
  • Trần Quang Dũng Bệnh viện Trung ương Quân đội 108
  • Đặng Hoài Lân Bệnh viện Trung ương Quân đội 108
  • Vũ Quang Tiệp Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

Intracranial tumor, ultrasound, navigation system

Abstract

Objective: To evaluate the effect of intraoperative navigated ultrasonography in intracranial tumor resection. Subject and method: 32 intracranial tumor patients were undergoing surgical treatment with intraoperative navigated ultrasonography at Neurosurgery Department of 108 Military Central Hospital from January to May 2020. After resection was completed, the cavity borders of all patients were examined with a 13MHz intraoperative probe. Any echogenic region > 5mm in thickness extending from the surgical cavity into the brain substance was taken as the sonographic criterion for residual tumor. A continuous echogenic rim < 5mm was considered normal. Results were correlated with gadolinium-enhanced MRI obtained within 48 hours after surgery. Result: The Kappa value for inter-method agreement was 0.72. There were four cases in whom MRI showed residue despite a negative sonography: Extensive edema or surgicel along the cavity borders (2 cases with glioblastoma multiforme; 1 case metastatic carcinoma and 1 case anaplastic astrocytoma) may be the reason for the residue going undetected. Conclusion: Intraoperative navigated ultrasonography is an effective tool for maximizing the extent of intracranial tumor resection.

Article Details

References

1. Erdogan N, Tucer B, Mavli E, Menkü A, Kurtsoy A (2005) Ultrasound guidance in intracranial tumor resection: Correlation with postoperative magnetic resonance findings. Acta Radiol 46: 743-749.
2. Sweeney JF, Smith H, Taplin A, Perloff E, Adamo, MA (2018) Efficacy of intraoperative ultrasonography in neurosurgical tumor resection. J. Neurosurg. Pediatr 21: 504-510.
3. Bal J, Camp SJ, Nandi D (2016) The use of ultrasound in intracranial tumor surgery. Acta. Neurochir (Wien.) 158: 1179-1185.
4. Sastry R, Bi WL, Pieper S, Frisken S, Kapur T, Wells W, Golby AJ (2017) Applications of ultrasound in the resection of brain tumors. J. Neuroimaging 27: 5-15.
5. Woydt M, Krone A, Becker G, Schmidt K, Roggendorf W, Roosen K (1996) Correlation of intraoperative ultrasound with histopathologic findings after tumor resection in supratentorial gliomas. Acta Neurochir 138: 1391-1398.
6. Gerard I, Kersten-Oertel M, Petrecca K, Sirhan D, Hall JA, Collins DL (2017) Brain shift in neuronavigation of brain tumors: A review. Med. Image Anal 35: 403-420.
7. Ilunga-Mbuyamba E, Avina-Cervantes JG, Lindner D, Arlt F, Ituna-Yudonago JF, Chalopin C (2018) Patient-specific model-based segmentation of brain tumors in 3D intraoperative ultrasound images. Int. J. Comput. Assist. Radiol. Surg 13: 331-342.
8. Moiyadi A, Shetty P (2011) Objective assessment of utility of intraoperative ultrasound in resection of central nervous system tumors: A cost-effective tool for intraoperative navigation in neurosurgery. J. Neurosci. Rural Pract 2: 4-11.
9. Sæther CA, Torsteinsen M, Torp SH, Sundstrom S, Unsgård G, Solheim O (2012) Did survival improve after the implementation of intraoperative neuronavigation and 3d ultrasound in glioblastoma surgery? A retrospective analysis of 192 primary operations. J. Neurol. Surg. A Cent. Eur. Neurosurg 73: 73-78.
10. Coburger J, König RW, Scheuerle A, Engelke J, Hlavac M, Thal DR, Wirtz CR (2014) Navigated high frequency ultrasound: Description of technique and clinical comparison with conventional intracranial ultrasound. World Neurosurg 82: 366-375.
11. Lindner D, Trantakis C, Renner C, Arnold S, Schmitgen, A Schneider J, Meixensberger J (2016) Application of intraoperative 3D ultrasound during navigated tumor resection. Minim. Invasive Neurosurg 49: 197–202.
12. Prada F, Del Bene M, Mattei L, Casali C, Filippini A, Legnani F, Mangraviti A, Saladino A, Perin A, Richetta C et al (2014) Fusion imaging for intra-operative ultrasound-based navigation in neurosurgery. J. Ultrasound 17: 243-251.
13. Albert FK, Forsting M, Sartor K, Adams HP, Kunze S. (1994) Early postoperative magnetic resonance imaging after resection of malignant glioma: Objective evaluation of residual tumor and its influence on regrowth and prognosis. Neurosurgery 4: 45-60.