Mối liên quan giữa tính đa hình gen mã hoá thụ thể vitamin D và biểu hiện lâm sàng ở bệnh nhân nhiễm vi rút viêm gan B mạn tính

Abstract

Objective: This study is to investigate the association of VDR variants [TaqI (rs731236), FokI (rs10735810), ApaI (rs7975232) and BsmI (rs1544410)] with HBV susscetiblity and liver disease progression in chronic HBV infection. This study also evaluates the relationship between these VDR variants and the serum vitamin D levels in HBV-infected patients. Subject and method: This study is designed as a case-control study involved 298 patients [CHB (n = 104), LC (n = 89), HCC (n = 105)] and 52 healthy people (HC). VDR genotyping was performed by ARMS-PCR. Result: The frequency of genotype ApaI rs7975232 GT and allele T was significantly lower in HBV infected patiens compared to HC [OR = 0.3 (0.1 - 0.6), p=0.006 and OR = 0.7 (0.5 - 0.98), p=0.048]. VDR-AapI rs7975232 TT was significantly associated with liver disease progression [HCC vs. CHB: OR = 3.7 (1.1 - 13.5), p=0.041]. Both VDR variants ApaI and FokI were associated with vitamin D levels in the serum in HBV infected patients. Conclusion: The significant association of VDR variant ApaI (rs7975232) with the susceptibility to HBV infection and the clinical outcomes of HBV infected patients. Additionally, ApaI and FokI variant may be a genetic factor supporting the valuation of vitamin D levels in HBV infected patients.