ISSN: 1859 - 2872
Study on clinical, subclinical characteristics, serum immunoglobulins concentration during and after of acute exacerbation of chronic obstructive pulmonary disease
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Abstract
Objective: To describe the clinical, subclinical characteristics and serum immunoglobulin concentrations during and after of acute exacerbations (AE) of chronic obstructive pulmonary disease (COPD). Subject and method: A prospective observational study. 127 cases were enrolled: 30 healthy persons in control group and 97 patients with AE of COPD, being treated at 103 Military Hospital from October 2015 to August 2017. Result: Severe and very severe dyspnea accounted for the highest proportion, average mMRC score of 3.2 ± 0.7. Life-threatening AE accounted for 43.3%. Increased number of leukocytes was 54.6%. Disorders of blood glucose and kidney function were common, increasing serum PCT levels by 54.6%, and CRP by 68%. Increased pCO2 was 47.4% and respiratory acidosis was 33% in arterial blood gas in AE. The serum concentration of IgG, IgG1 during and after of AE were lower than the control group. The serum concentration of IgA in COPD patients were higher than control group (p<0.001). Conclusion: Severe clinical symptoms accounted for a high proportion in AE and life-threatening AE accounted for 43.3%. Leukocytosis, increased serum PCT and CRP levels were common in AE. Serum IgG concentrations during and after of AE were significantly lower than in the control group.
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2. Phạm Kim Liên (2012) Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và biến đổi một số cytokine ở bệnh nhân bệnh phổi tắc nghẽn mạn tính. Luận án tiến sỹ, Học viện Quân y.
3. Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J et al (2020) Global strategy for diagnosis, management and prevention of COPD 2020 update. Guidelines.
4. Cowan J, Gaudet L, Mulpuru S et al (2015) A retrospective longitudinal within-subject risk Interval analysis of immunoglobulin treatment for recurrent acute exacerbation of chronic obstructive pulmonary disease. PLoS ONE 10(11): e0142205.
5. Aburto M, Esteban C, Moraza FJ et al (2011) COPD exacerbation: Mortality prognosis factors in a pespiratory care unit. Arch Bronconeumol Engl Ed 47(2): 79-84.
6. Roche N, Zureik M, Soussan D et al (2008) Predictors of outcomes in COPD exacerbation cases presenting to the emergency department. Eur Respir J 32(4): 953-961.
7. Saldías PF, Díaz PO, Dreyse DJ et al (2012) Etiology and biomarkers of systemic inflammation in mild to moderate COPD exacerbations. Rev Médica Chile 140(1): 10-18.
8. Xiao K, Guo C, Su L et al (2015) Prognostic value of different scoring models in patients with multiple organ dysfunction syndrome associated with acute COPD exacerbation. J Thorac Dis 7(3): 329–336.
9. Kim JH, Park S, Hwang YI et al (2016) Immunoglobulin G subclass deficiencies in adult patients with chronic airway diseases. J Korean Med Sci 31(10): 1560-1565.
10. Samea ERA, Al Baiomy A, El-Desoky M et al (2011) Value of serum ECP and IgE in differentiation between asthma and COPD. New York Science Journal 4(4): 1-7.
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