ISSN: 1859 - 2872
Change of serum haptoglobin level in patients with hepatocellular carcinoma
Main Article Content
Keywords
Abstract
Summary
Objective: To evaluate the change of serum haptoglobin (Hp) level in patients with hepatocellular carcinoma (HCC) and the relationship with characteristics and stage of tumours. Subject and method: A prospective, cross-sectional descriptive study carried out on 77 patients with HCC in Digestive Department of 103 Military Hospital and the 108 Military Central Hospital. Serum Hp concentration was determined by immunoturbidimetric assays. Result: Serum Hp levels in patients with HCC was 1.05 ± 0.56 (g/L), no significantly higher than that in control group (1.08 ± 0.48g/L), p>0.05. There was a significant relationship between serum Hp levels and portal venous thrombosis and Barcelona staging classification. Conclusion: Serum Hp concentration was significantly associated with Barcelona staging classification in patients with HCC.
Keywords: Haptoglobin, hepatocellular carcinoma.
Article Details
References
2. Bộ Y tế (2012) Hướng dẫn chẩn đoán và điều trị ung thư gan nguyên phát. Quyết định số 5250/QĐ-BYT.
3. Bray F, Ferlay J et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA cancer journal for clinicians 68(6): 394-424.
4. Butterfield LH (2007) Recent advances in immunotherapy for hepatocellular cancer. Swiss Med Wkly 137(5-6): 83-90.
5. Dalal B, Dalal K, Bhatia S et al (2019) Analysis of serum Haptoglobin using glycoproteomics and lectin immunoassay in liver diseases in Hepatitis B virus infection. Clin Chim Acta 495: 309-319.
6. Shang S, Li W et al (2017) Aided diagnosis of hepatocellular carcinoma using serum fucosylated haptoglobin ratios. J Cancer 8(5): 887-893.
7. Tai CS, Lin YR et al (2017) Haptoglobin expression correlates with tumor differentiation and five-year overall survival rate in hepatocellular carcinoma. PLoS One 12(2): 0171269.
8. Tublin ME, Dodd GD et al (1997) Benign and malignant portal vein thrombosis: Differentiation by CT characteristics. AJR Am J Roentgenol 168(3): 719-723.
9. Shu H, Kang X et al (2010) Diagnostic value of serum haptoglobin protein as hepatocellular carcinoma candidate marker complementary to alpha fetoprotein. Oncol Rep 24(5): 1271-1276.
10. Subramaniam S, Kelley RK et al (2013) A review of hepatocellular carcinoma (HCC) staging systems. Chin Clin Oncol 2(4): 33.
11. Sun L Hu S et al (2016) Serum haptoglobin as a novel molecular biomarker predicting colorectal cancer hepatic metastasis. Int J Cancer 138(11): 2724-2731.
12. Zhu J, Lin Z et al (2014) Analysis of serum haptoglobin fucosylation in hepatocellular carcinoma and liver cirrhosis of different etiologies. J Proteome Res 13(6): 2986-2997.
Article Sidebar
