ISSN: 1859 - 2872
Study of changes in zinc and copper concentrations before and after psoriasis vulgaris treatment by narrow band ultraviolet irradiation (UVB-311nm) plus low dose methotrexate
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Abstract
Summary
Objective: To evaluate changes in zinc (Zn) and copper (Cu) concentrations before and after psoriasis vulgaris treated by UVB-311nm irradiation combined with low dose methotrexate (MTX) 7.5mg/week at Dep. of Dermatology and Venereology, 108 Military Central Hospital. Subject and method: 35 patients with moderate and severe psoriasis vulgaris are exposed to UVB-311nm once a day for 5 days/week plus oral dose of 7.5mg/week × 4 weeks and have blood drawn to quantify Zn and Cu before and after 4 weeks of inpatient treatment compared with 32 control groups (healthy people). Result: Before treatment, concentration of Zn in the serum of patients with psoriasis vulgaris before treatment decreased compared to the control group (p<0.05), while Cu did not mean change p>0.05. After treatment, Zn concentration increased more than before treatment with p<0.05 and Cu concentration, the change was not statistically significant, with p>0.05. Conclusion: UVB-311nm irradiation combined with low dose MTX when PASI decreased by 69% resulted in increased Zn concentration in blood while Cu concentration remained unchanged.
Keywords: Psoriasis vulgaris, UVB-311nm, methotrexate, Zinc, Copper.
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References
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