Nghiên cứu căn nguyên và tình trạng kháng kháng sinh của vi khuẩn ở bệnh nhân nhiễm khuẩn huyết do viêm đường mật tại Bệnh viện Trung ương Quân đội 108

Abstract

Objective: To determine the pathogenic bacteria from blood samples of septic patients caused by cholangitis and to evaluate their antibiotic resistance. Subject and method: A retrospective and descriptive study was conducted which enrolled 95 septic patients caused by cholangitis at the 108 Military Central Hospital in the period from March 2015 to November 2018. Result: Only gram negative bacteria were identified by blood culture. The predominant pathogentic bacteria were E. coli, K. pneumoniae, P. aeruginosa with the frequency of 64.2%, 13.7%, 6.3%, respectively. High frequency of antibiotic resistance with the third or fourth generation cephalosporin was significantly recorded by the rate from 60% to 70%. The bacterial isolates were highly resistant with fluoroquinolone antibiotics group, such as ciprofloxacin with the rate of 45.5%. Meanwhile, 66.7% and 92.4% bacterial species were susceptive with amikacin and gentamicin, respectively. Specially, all E.coli isolates were susceptive with amikacin. Carbapenems are a class of the highest effective antibiotic agents to all gram negative bacterial strains isolated from blood samples with the susceptibility from 92.4% to 98.4%. Other antibiotics were still had highly susceptive like piperacillin/tazobactam, colistin. Conclusion: The present study showed that the most of E. coli, K. pneumoniae, P. aeruginosa were found from the blood samples of septic patients caused by cholangitis. The bacterial isolates were highly susceptible to amikacin, carbapenem, piperacillin/tazobactam and colistin.