Hiệu quả điều trị kẹp clip đơn thuần và kẹp clip kết hợp tiêm adrenaline trong điều trị chảy máu tiêu hóa do loét dạ dày - tá tràng

Abstract

Objective: To compare hemoclips + adrenaline injection with hemoclips alone for the treatment of bleeding due to gastroduodenal ulcer. Subject and method: 150 patients with major stigmata of gastroduodenal ulcer bleeding were randomly assigned to receive hemoclips + adrenaline (n = 75) and hemoclips alone (n = 78). All patients were received clinical examination, laboratory tests, and upper gastrointestinal endoscopy. The primary end point of rebleeding rate, initial hemostasis rate, need for surgery rate and mortality were compared between the two groups. Result: Initial hemostasis was achieved in 75/75 patients (100%) of the hemoclips + adrenaline group and 68/75 (90.7%) of the hemoclips alone (p<0.05). The rate of recurrent gastrointestinal bleeding, blood transfusions, hospital stays, surgical rate of the group hemoclips + adrenaline were significantly lower (p<0.05) compared with patients with hemoclips alone (p<0.05). Side effects included sore throat, nausea and vomiting, light epigastric pain with no differences between the 2 groups. Conclusion: Combination therapy (clip + adrenaline) was better efficiency than clip alone.