Change of red cell morphology in patients with cirrhosis

  • Huy Duong Quang 103 Millitary Medical Hospital
  • Chung Nguyen Duc 105 Millitary Medical Hospital
  • Hanh Nguyen Thi Hien 103 Millitary Medical Hospital

Main Article Content

Keywords

Acanthocyte, red cell morphology, cirrhosis

Abstract

Objective: To evaluate the change of red cell morphology in peripheral blood in cirrhotic patients and its relationship with liver dysfunction. Subject and method: Prospective, cross-sectional descriptive study carried out on 70 patients with cirrhosis in Digestive Department of 103 Military Hospital. The determination of presence of spur cell on peripheral blood smear at ×100 magnification under oil immersion. Result: Prevalence of spur cell on peripheral blood smear in cirrhotic patients was 44.3%. Patients with spur cells had more advanced liver disease higher Child-Pugh score (9.4 ± 2.2 vs 8.0 ± 1.9, p=0.006) and higher prevalence in Child-Pugh C cirrhosis compared with Child-Pugh B/A cirrhosis (70.8% vs 31.4% and 23.7%, respectively, p<0.05). Conclusion: The presence of spur cell was quite common in patients with cirrhosis and had the correlation with liver dysfunction.


 

Article Details

References

1. Trần Phạm Chí (2014) Nghiên cứu hiệu quả thắt giãn tĩnh mạch thực quản kết hợp propranolol trong dự phòng xuất huyết tái phát và tác động lên bệnh dạ dày tăng áp cửa do xơ gan. Luận án Tiến sỹ y học, Trường Đại học Y dược Huế.
2. Alexopoulou A, Vasilieva L, Kanellopoulou T et al (2013) Presence of spur cells as a highly predictive factor of mortality in patients with cirrhosis. Jounal of Gastroenterology and Hepatology 29: 830-834.
3. Privieta G, Meli G (2016) An unusual cause of anemia in cirrhosis: Spur cell anemia, a case report with review of literature. Gastroenterology and Hepatology 9(4): 335-339.
4. Sousa JM, Giraldez A, De Blas JM et al (2002) Spur cell anemia in hepatic cirrhosis: Incidence, prognosis and reversibility after liver transplantation. J Hepatol 36: 64.
5. Vassiliadis T, Mpoumponaris A, Vakalopoulou S et al (2010) Spur cells and spur cell anemia in hospitalized patients with advanced liver disease: Incidence and correlation with disease severity and survival. Hepatology Research 40: 161-170.
6. Qamar AA, Grace ND (2009) Abnormal hematological indices in cirrhosis. Can J Gastroenterol 23(6): 441-445.