ISSN: 1859 - 2872
Value of NT-proBNP in diagnosis of hyponatremia causes in brain haemorrhage patients
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Abstract
Objective: To evaluate the value of NT-proBNP in diagnosing the causes of hyponatremia in patients with cerebral hemorrhage: Cerebral salt-wasting syndrome (CSWS) and syndrome of inappropriate antidiuretic hormone (SIADH). Subject and method: A descriptive, prospective study of 86 patients with cerebral hemorrhage and hyponatremia. The NT-proBNP testings were performed when hyponatremia were detected in these patients. They were treated, followed up and determined the causes of hyponatremia. Result: There were 31 CSWS and 47 SIADH patients. The causes of hyponatremia were not identified in 8 patients. The average plasma NT-proBNP level of patients was 240.5 ± 274.7pg/ml. There was no statistically significant correlation between NT-proBNP concentrations and NISSH scores. The mean NT-proBNP concentration in patients with hyponatremia caused by CSWS (420.1 ± 285.5pg/ml) was higher than that of SIADH group (107.1 ± 133.1pg/ml) with p<0.05. The sensitivity, specificity, positive predictive value and negative predictive value of NT-proBNP at cut-off point of 183pg/ml were 86.67, 87.23%, 81.8 and 91%, respectively. Conclusion: At the cut–off point of 183pg/ml, NT-proBNP showed sensitivity 86.67%, specificity 87.23%, positive predictive value 81.8% and the negative predictive value 91% in diagnosis of hyponatremia caused by CSWS.
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References
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