Đánh giá đặc điểm các biến cố bất lợi của một số phác đồ điều trị ung thư đại trực tràng tại Bệnh viện Trung ương Quân đội 108 giai đoạn 2015 - 2017

Abstract

Objective: To evaluate the adverse drug events (ADE) basing on the toxicity levels of colorectal cancer patients at various cycles of their specific therapeutics regiments. Subject and method: From 1/1/2015 to 31/12/2015, 115 colorectal cancer patients were recruited and initiated their treatment with chemotherapies; level of toxicity were also recorded right upon the initiation of patients’ first cycle of chemotherapies and continued until 31/12/2017. Result and conclusion: There were 3463 ADE recorded, with an average of 2.7 ADE per treatment, 10 out of the identified ADEs were noted with the highest incidence. ADEs were mostly categorized grade 1 and 2, only very of the identified ADE were graded 3 and 4. In details of individual therapeutics regiments, we saw that nausea and fatigue events were more common in all regimens, however, FOLFOX4 had the lowest incidence (p<0.05). If look at the length of treatment cycle, we observed that the incidence of nausea was the highest in the cyclical range of 10 - 12 (74.6%); this adversity got the lowest incidence in cycles 1 - 3 (48.1%) (p<0.05). Whereas the other adverse events like injection site reactions, paresthesias and elevated AST occurred at all cycles and increased incidence at subsequent cycles (p<0.05).