Effect of Truong Xuan CB capsules on some parameters of hematology, biochemical and macroscopic, microscopic images of rats

  • Vu Ngoc Thang Vietnam Military Medical University
  • Nguyen Hoang Ngan Vietnam Military Medical University
  • Nguyen Minh Phuong Vietnam Military Medical University
  • Pham Vinh Truong 108 Military Central Hospital

Main Article Content

Keywords

Biochemical parameters, hematology, Truong Xuan CB

Abstract

Summary


Objective: To evaluate the effect of Truong Xuan CB capsules (TXCB) on some hematological parameters, blood biochemistry, macroscopic and microscopic images of some organs on rats. Subject and method: TXBC were obtained from the provincial research project, meeting the house standard. Research was conducted according to the OECD 408 Guideline. Result: There were no significant differences (p>0.05) in the red blood cell, hematocrit, hemoglobin, mean corpuscular volume, white blood cell, platelet count, the levels of AST, ALT, creatinine, albumin, cholesterol in the TXCB groups when compared to the control group. No significant changes were observed in the macroscopic and microscopic images of the liver, spleen, and kidneys of the rats in the TXCB groups. Conclusion: TXCB capsules at doses of 0.42g/kg and 1.26g/kg were not affect to the hematology, biochemical parameters and macroscopic, microscopic images of liver, spleen and kidney when taken continuously for 90 days.


Keywords: Biochemical parameters, hematology, Truong Xuan CB.


 

Article Details

References

1. Phạm Thị Nguyệt Hằng, Nguyễn Văn Khiêm và Nguyễn Văn Khởi (2017) Nghiên cứu độc tính cấp, bán trường diễn và tác dụng tăng lực của cao chiết cồn sâm cau. Tạp chí Dược liệu, 4(22), tr. 239-247.
2. OECD (2018) Test No. 408: Repeated dose 90-day oral toxicity study in rodents. OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, https://doi.org/10.1787.
3. Len EL, Norman JT and Florence LZ (1996) Reference values for young normal Sprague-Dawley rats: Weight gain, hematology and clinical chemistry. Human & experimental toxicology 15(8): 612-616.
4. Harry O, Graham B, Denise R et al (2000) Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicology and Pharmacology 32(1): 56-67.
5. Nachman B and John W (2002) Industrial solvents and liver toxicity: Risk assessment, risk factors and mechanisms. International journal of hygiene and environmental health 205(6): 479-491.
6. Sherrill JS (2004) Relationship between platelet count and bleeding risk in thrombocytopenic patients. Transfusion medicine reviews 18(3): 153-167.
7. Norbert L, Wim VB and Raymond V (2006) The changing epidemiology of acute renal failure. Nature Clinical Practice Nephrology 2(7): 364-377.
8. Elumalai A, Chandiran IS and Balamuthu K (2013) An investigation on preliminary phytochemical and safety profiles of methanolic root extract of Curculigo orchioides. Journal of pharmacy research 7(8): 692-696.
9. Ma H, He X, Yang Y et al (2011) The genus epimedium: An ethnopharmacological and phytochemical review. Journal of ethnopharmacology 134(3): 519-541.
10. Zhang JH, Xin HL, Xu YM et al (2018) Morinda officinalis How.–A comprehensive review of traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology 213: 230-255.
11. Harunobu A and Norman RF (2011) A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Food research international 44(7): 1702-1717.
12. Zhao Z, Liu P, Ma S et al (2017) Botanical characteristics, chemical and nutritional composition and pharmacological and toxicological effects of medicinal and edible plant Millettia speciosa Champ. Food Science 38(9): 293-306.