The research of plasma microRNAs as potential biomarkers in the diagnosis of sepsis

  • Tran Thi Lien 108 Military Central Hospital
  • Ngo Tat Trung 108 Military Central Hospital
  • Vu Viet Sang 108 Military Central Hospital
  • Le Huu Song 108 Military Central Hospital

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Keywords

Sepsis, microRNA 146-3p, microRNA 147b, microRNA-155, microRNA 223

Abstract

Summary


Objective: To investigate the value of four circulating microRNAs (microRNA: microRNA-155, microRNA-147b, microRNA-223, microRNA-146-3p) in diagnosis of sepsis. Subject and method: 71 sepsis patients treated in Viet-Tiep Hospital, Hai Phong and 108 Military Central Hospital, Ha Noi from November, 2014 to July, 2017 there are 31 Dengue haemorrhagic fever (DHF) patients and 32 healthy control (HC) were included in the control group. The expression of microRNA-146-3p, microRNA-147b, microRNA-155, microRNA-223 were measured by q-RT-PCR. Result and conclusion: The expression of 4 microRNAs: MicroRNA-146-3p, microRNA-147b, microRNA-155, microRNA-223 in sepsis group was significantly higher than that in healthy control and DHF group (p<0.05). MicroRNA-146-3p and microRNA-147b were good at discrimination sepsis and healthy people and DHF with AUC 0.87 & 0.77 (p<0.01) and 0.90 & 0.78 (p<0.01). Moreover, microRNA-146-3p (AUC: 0.77) and microRNA-147b (AUC: 0.78) were fair at discrimination sepsis and DHF.


 Keyworks: Sepsis, microRNA 146-3p, microRNA 147b, microRNA-155, microRNA 223.


 

Article Details

References

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Published
Jul 7, 2020
Issue
Volume 15 - No 7/2020
Section
Articles
How to Cite
Thi LienT., Tat TrungN., Viet SangV., & Huu SongL. (2020). The research of plasma microRNAs as potential biomarkers in the diagnosis of sepsis. Tạp Chí Y Dược lâm sàng 108, 15(7). Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/488