ISSN: 1859 - 2872
Antibiotic resistance characteristics and risk factors for nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae at Bach Mai Hospital's Intensive Care Unit from July 2019 to August 2020
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Abstract
Summary
Objective: To describe antibiotic resistance characteristics and risk factors for nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). Subject and method: This was a prospective, case-control observational study using logistic regression analysis on 60 patients were diagnosed with Klebsiella pneumoniae infection nosocomial. This study was perfomed at Bach Mai Hospital from July 2019 to August 2020. Result: The strains of K. pneumoniae subdivided were most resistant to antibiotic groups, of which the resistance to carbapenem was 78.3-80%. These strains were also relatively high sensitive to fosfomycin (60.0%), amikacin (75.0%), and colistin (86.7%). Comparing the resistance rates of the CRKP group were both higher than that of the carbapenem susceptible K. pneumoniae group, and significantly in cephalosporin and quinolone antibiotics. Risk factors for CRKP infection: Exposure to carbapenem or colistin in the past 30 days; tracheal intubation; mechanical ventilation; total parenteral nutrition; surgery within the past 3 months; nasogastric catheter intubation; in which exposure to carbapenem in the past 30 days were identified as independent risk factors in multivariate analysis. Conclusion: The rate of K. pneumoniae resistant to carbapenem was 80%. The previous 30-day history of carbapenem was the highest risk factor for increasing the likelihood of nosocomial infections caused by carbapenem-resistant K. pneumoniae.
Keywords: K. pneumoniae, carbapenem-resistant K. pneumoniae (CRKP), hospital infection, risk factor.
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References
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