ISSN: 1859 - 2872
Study on some clinical characteristics and concentrations of apolipoproteins in plasma of patients with atherosclerotic cerebral infarction
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Summary
Objective: To evaluate some clinical characteristics and changes of apolipoprotein A-I, apolipoprotein B, apolipoprotein B/apolipoprotein A-I ratio in plasma of patients with atherosclerotic cerebral infarction. Subject and method: 248 patients with cerebral infarction patients were examined and treated at 108 Military Central Hospital from 10/2017-12/2019. Patients were examined clinically, diagnosed with imaging and tested apoA-I, apoB, apoB/apoA-I ratio on admission. Result: The average age of patients with atherosclerotic cerebral infarction was 63.75 ± 12.64 years; male make up for 80.82% of the number of patients. Muscle strength of upper extremities, muscle strength of lower extremities of the atherosclerotic cerebral infarction group (2.04 ± 1.65, 3.05 ± 1.49) were lower than those of the other cerebral infarction group (2.21 ± 1.64; 3.16 ± 1.36) with p<0.01. The Glasgow scores of the atherosclerotic cerebral infarction group (13 ± 2.6) was lower than that of the other cerebral infarction group (14.8 ± 0.6) with p<0.01. The NIHSS on admission of the atherosclerotic cerebral infarction group (12.95 ± 8.51) was higher than that of the other cerebral infarction group (6.14 ± 4.63) with p<0.01. The apoA-I concentration of the other cerebral infarction group (1.51 ± 0.286g/l) was higher than that of the atherosclerotic cerebral infarction group (1.28 ± 0.23g/l) with p<0.05. The apoB concentration of the atherosclerotic cerebral infarction group (1.31 ± 0.29g/l) was higher than that of the other cerebral infarction group (1.03 ± 0.27g/l) with p<0.05. The apoB/apoA-I ratio of the atherosclerotic cerebral infarction group (1.06 ± 0.34) was higher than that of the other cerebral infarction group (0.7 ± 0.23) with p<0.05. Conclusion: Some clinical features (paralysis, disturbance of consciousness, degree of stroke) of patients with atherosclerotic cerebral infarction are more severe than those of patients with other cerebral infarction. There are changes in the apoA-I concentration, apoB concentration and the apoB/apoB-I ratio in plasma of patients with atherosclerotic cerebral infarction.
Keywords: Cerebral infarction, apoA-I, apoB concentration, apoB/apoA-I ratio.
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2. Nguyễn Thị Mơ, Nguyễn Văn Thông, Nguyễn Hồng Quân (2012) Đánh giá hiệu quả công tác chăm sóc bệnh nhân đột quỵ chảy máu não cấp tại Trung tâm Đột quỵ - Bệnh viện TWQĐ 108. Tạp chí Y Dược lâm sàng 108, tập 7 số đặc biệt, 10/2012, tr. 271-279.
3. Nguyễn Hoàng Ngọc (2012) Nghiên cứu đặc điểm lâm sàng, yếu tố nguy cơ và tiên lượng hậu quả chức năng các bệnh nhân nhồi máu não cấp. Tạp chí Y dược lâm sàng 108, tập 7- số đặc biệt tháng 10/2012, tr. 208-216.
4. Nguyễn Văn Thông, Nguyễn Hoàng Ngọc, Nguyễn Hồng Quân, Đỗ Mai Huyền, Lê Đình Toàn, Nguyễn Văn Tuyến, Đinh Thị Hải Hà (2010) Đánh giá hiệu quả điều trị 1162 bệnh nhân đột quỵ thiếu máu não tại Trung tâm Đột quỵ - Bệnh viện Trung ương Quân đội 108. Tạp chí Y dược Lâm sàng 108, tập 5 - Số đặc biệt tháng 10/2010, tr. 13-24.
5. Béjot Y, Bailly H, Durier J, & Giroud M (2016) Epidemiology of stroke in Europe and trends for the 21st century. La Presse Médicale 45(12): 391-398.
6. Coupland AP, Thapar A, Qureshi MI, Jenkins H & Davies AH (2017) The definition of stroke. Journal of the Royal Society of Medicine 110(1): 9-12.
7. Eka Rhestifujiayani, Emil Huriani, Muharriza. (2015) Comparison of muscle strength in stroke patients between the given and not given range of motion exercise. Nurse Media Journal of Nursing 5(2): 88-100.
8. Harold P, Adams Jr, Birgitte H Bendixen Jaap Kappelle L, Jose Biller, Betsy B. Love, David Lee Gordon, E. Eugene Marsh III, and TOAST Investigators (1993) Classification of Subtype of acute ischemic stroke definitions for use in a multicenter clinical trial. Stroke 24(1): 35-41.
9. Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G (2009) Relationships between lipoprotein components and risk of ischaemic and haemorrhagic stroke in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med 265: 275-287.
10. Kim SH, Lee JY, Park SH, Jang HC, Lim EJ, Chang SJ, & Lee SS (2013) Plasma B-type natriuretic peptide level in patients with acute cerebral infarction according to infarction subtype and infarction volume. International Journal of Medical Sciences 10(1): 103-109.
11. Moustafa RR, Moneim AA, Salem HH, Shalash AS, & Azmy HA (2012) Intracranial steno-occlusive arterial disease and its associations in egyptian ischemic stroke patients. Stroke 44(2): 538-541.
12. Scott W, Roger B, Mary SR, Lawrence M, Steven S, and Gray Ellrodt A (1990) The principle of parsimony: Glasgow coma scale score predicts mortality as wellas the APACHE II Score for Stroke Patients. Stroke Severity-of-Illn 21(9): 1280-1282.
13. ShilpaSree AS, Savitri S, JayapraKaSh M, Kiran K (2013) A study of serum apolipoprotein A1, apolipoprotein B and lipid profile in stroke. Journal of clinical and diagnostic research: 1303-1306.
14. Walldius G, Junger I (2006) The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy - a review of the evidence. Journal of Internal Medicine 259(5): 493-519.
15. Zahra-Sadat H, Hamid P Mahmoodreza G (2019) The effect of early passive range of motion exercise on motor function of people with stroke: A randomized controlled trial. Journal of Caring Sciences 8(1): 39-44.
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