ISSN: 1859 - 2872
Study on clinical and laboratory features of advanced hepatocellular carcinoma in patients with vein thrombosis
Main Article Content
Keywords
Abstract
Objective: To investigate clinical and laboratory features of hepatocellular carcinoma (HCC) with portal vein thrombosis. Subject and method: 101 HCC patients with portal vein (PV) thrombosis were enrolled in this descriptive, cross-sectional study. Result: The age average of subjects is 54.2 ± 11.7 and the male/female ratio is 13.4/1. 85.1% of patients are HBV-positive while 44.6% of them are alcoholic. Common clinical findings include right upper quadrant discomfort (94.1%), fatigue (84.2%), anorexia (77.2%), weight loss (65.3%) and hepatomegaly (43.6%). AFP is highly elevated in 84.2% of patients. The majority of tumor is located on the right lobe, the mean size of tumor is 10.89 ± 3.7cm and 57.4% of patients have tumor larger than 10cm. Conclusion: Symptomatic liver tumor are usually found on late stages with severe symptoms and large sizes.
Article Details
References
2. Bộ Y tế Việt Nam (2012) Hướng dẫn chẩn đoán và điều trị ung thư tế bào gan nguyên phát. Quyết định số 5250/QĐ-BYT.
3. Nguyễn Tiến Thịnh (2012) Nghiên cứu hiệu quả điều trị ung thư biểu mô tế bào gan bằng phương pháp tắc mạch hóa dầu đơn thuần và tắc mạch hóa dầu kết hợp đốt nhiệt cao tần. Luận án Tiến sỹ Y học, Viện Nghiên cứu Khoa học Y Dược lâm sàng 108.
4. Floridi C et al (2017) Yttrium-90 radioembolization treatment for unresectable hepatocellular carcinoma: A single-centre prognostic factors analysis. Medical Oncology 34(10): 174.
5. Daichi T et al (2007) Hepatocellular carcinoma with portal vein tumor thrombosis: Clinical characteristics, prognosis and patient survival analysis. Digestive diseases and sciences 52(11): 3290-3295.
6. Jie S, Eric CH, Lai, Nam Li et al (2011) A new classification for hepatocellular carcinoma with portal vein tumor thrombus. J Hepatobiliary Pancreat Sci 18: 74-80.
7. Gregory CC et al (2008) Incidence, risk factors and consequences of portal vein and systemic thromboses in hepatocellular carcinoma. Thrombosis research 122(3): 299-306.
9. Tublin ME, Dodd GD, Baron RL (1997) Benign and malignant portal vein thrombosis: Differentiation by CT characteristics. AJR 168: 719-723.
10. Lin Zhou, Jia Liu, and Feng Luo (2006) Serum tumor markers for detection of hepatocellular carcinoma. World journal of gastroenterology, WJG 12(8): 1175.
11. Tenzin N, Prashant P et al (2011) Portal vein thrombosis-clinical profile. JIACM 12(2): 134-140.
Article Sidebar
