ISSN: 1859 - 2872
Evaluating pathological features according to hormone receptor-negative breast cancer molecular subtypes
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Abstract
Summary
Objective: To determine some relations between pathological features and negative hormone receptor breast cancer molecular subtypes. Subject and method: 202 hormone receptor-negative breast cancer patients underwent immunohistochemistry (IHC) staining for molecular categories and evaluating the relationship with pathological features. Result: Triple negative non basal-like (TNB-), triple negative basal-like (TNB+) and HER2 types accounted for highest rates in high Ki67 (55.6%, 55.3%, and 51.5%; respectively), with highest rate in p53(+)Bcl2(-), were more common in patients with more than 3 positive nodes (27.8%, 22.4% and 22.3%, respectively), as well as in poor Nottingham prognostic index (NPI) subtype (p<0.001). Conclusion: The hormone receptor-negative breast cancer molecular subtypes are often associated with poor pathological features.
Keywords: Breast cancer, negative hormone receptor, molecular subtypes.
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References
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