ISSN: 1859 - 2872
Pathological characteristics of luminal molecular subtypes in breast cancer
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Abstract
Summary
Objective: To observe some relations between pathological features and luminal subtypes of breast cancer. Subject and method: 239 breast cancer patients were classified as luminal subtypes by immunohistochemistry staining and evaluated for relations with pathological characteristics. Result: In patients with low Ki67, p53(-)Bcl2(+) and good Nottingham prognostic index (NPI), luminal A (LUMA) subtype was more common than luminal B (LUMB) (with the following rates of 58.8%, 64.3%, 32.1% and 55.4%, 50.0%, 18.9%, respectively). Conclusion: LUMA subtype is associated with better pathological factors than LUMB one.
Keywords: Breast cancer, pathology, luminal molecular subtypes.
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References
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2. Bhargava R, Esposito NN and Dabbs DJ (2010) Immunohistology of the breast. Diagnostic Immunohistochemistry: Theranostic and genomic applications, Saunders, USA: 813-819.
3. Engstrøm MJ, Opdahl S, Hagen AI (2013) Molecular subnhómes, histopathological grade and survival in a historic cohort of breast cancer patients. Breast Cancer Res Treat 140: 463-473.
4. Krajewski S, Thor AD, Edgerton SM et al (1997) Breast cancers.Analysis of Bax and Bcl-2 expression in p53-immunopositive. Clin Cancer Res 3: 199-208.
5. Livasy CA, Karaca G, Nanda R et al (2006) Phenonhosmic evaluation of the basal-like subnhomes of invasive breast carcinoma. Modern Pathology 19: 264-271.
6. Perou CM, Sørlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406(6797): 747-752.
7. Sorlie T, Tibshirani R, Parker J et al (2003) Repeated observation of breast tumor subnhomes in independent gene expression data sets. Proc Natl Acad Sci USA 100(14): 8418-8423.
8. Spitale A, Mazzola P, Soldini D et al (2009) Breast cancer classification according to immunohistochemical markers: Clinicopathologic features and short-term survival analysis in a population-based study from the South of Switzerland. Annals of Oncology 20: 628-635.
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How to Cite
Văn ChủN., & Tiến QuangN. (2020). Pathological characteristics of luminal molecular subtypes in breast cancer. Tạp Chí Y Dược lâm sàng 108, 15(3). Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/430