ISSN: 1859 - 2872
Evaluation of the relationship between target organ damage and 24 hour-blood pressure variability in hypertensive patients over 60 years of age
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Summary
Objective: To investigate some target organ damages and the relationship between target organ damage and 24 hour-blood pressure variability in hypertensive patients over 60 years of age. Subject and method: A prospective, cross-sectional descriptive study, performed on all essential hypertensive patients treated at A1 Department - 108 Military Central Hospital from July 2016 to October 2017. The patients were followed 24-hour ambulatory blood pressure monitoring at A11 Department. Result: 83 hypertensive patients were mostly male, the average age was 72.9 ± 9.32. Time to detect hypertension ≥ 10 years accounted 41%. The target organ damage included: Heart 81.9%, brain 34.9%, eyes 61.4%, kidney 38.6%. The patient with non-dipper 73.5%, morning surge 65.1%. The patients with non-dipper that increased the risk cardiac organ damage OR = 4.3 (95% CI: 1.2 - 15.4, p=0.02), brain OR = 4.4 (95% CI: 1.2 - 20.9, p=0.04), eyes OR = 4.3 (95% CI: 1.2 - 14.6, p=0.01), kidney OR = 5.4 (95% CI: 1.1 - 19.3, p=0.02). The patients with morning surge that increased the risk cardiac organ damage OR = 3.6 (95% CI: 1.1 - 11.4, p=0.02), brain OR = 2.8 (95% CI: 1.0 - 8.1, p=0.04), eyes OR = 2.9 (95% CI: 1.1 - 7.4, p=0.02), there was no effect of morning surge hypertension on kidney damage. Conclusion: The rate of cardiac and eye damages were the highest. Most hypertensive patients have nocturnal non-dipper, over half of them appeared morning surge. Non-dipper and morning surge increased the risk cardiovascular, eyes, and brain. Non-dipper increased kidney damage.
Keywords: Essential hypertension, 24-hour ambulatory blood pressure monitoring, non-dipper, morning-surge.
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References
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