ISSN: 1859 - 2872
Clinical, MRI characteristics and the value of ADC in patients with acute ischemic stroke of unknown onset time at Military Hospital 103
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Abstract
Objective: To describe the clinical and MRI characteristics, and to determine the prognostic value of the ADC and rADC in patients with acute ischemic stroke of unknown onset time presenting with DWI-FLAIR mismatch on brain MRI. Subject and method: A retrospective and prospective, cross-sectional descriptive study was conducted in 40 patients with acute ischemic stroke of unknown onset time and DWI–FLAIR mismatch on brain MRI at the Stroke Department of Military Hospital 103. Result: The most common clinical manifestations were hemiparesis (95.0%), facial palsy (85.0%), and dysarthria (82.5%). Stroke onset during sleep was reported in 92.5% of patients. NIHSS scores were predominantly in the 6 - 10 range (52.5%). On brain MRI, 72.5% of patients had a single lesion, and 72.5% of lesions were less than or equal to 15 mm in diameter. The ADC_mean in the affected region and rADC differed significantly between patients with the NIHSS scores of 0-5 and 11 - 20 points groups and both parameters demonstrated value in discriminating early treatment outcomes, with AUC values of 0.759 (95% CI: 0.596 - 0.921) and 0.765 (95% CI: 0.577 - 0.953), respectively. Conclusion: The clinical and MRI characteristics of patients with acute ischemic stroke of unknown onset time with DWI-FLAIR mismatch were consistent with findings from previous studies. The ADC_mean in the affected region and rADC were associated with stroke severity and showd potential in discriminating early treatment outcomes after intravenous thrombolysis in this patient group.
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References
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