ISSN: 1859 - 2872
Evaluation of the effects of HA-coated ZK60 discs on cardiovascular function in an experimental animals
Main Article Content
Keywords
Abstract
Objective: To evaluate the effects of HA-coated ZK60 material discs on cardiovascular function in rabbits. Subject and method: Forty-eight white rabbits were randomly divided into three study groups, each consisting of 16 animals: Group 1 received HA-coated ZK60 material discs; Group 2 received uncoated ZK60 material discs; and Group 3 received titanium material discs. Electrocardiograms (ECGs) were recorded and analyzed using extended lead D2 at the following time points: Before surgery, and at 3, 7, 30, 60, 90, and 180 days post-surgery. Result: There were no statistically significant differences in heart rate, P wave amplitude and duration, R wave amplitude, QRS complex duration, or T wave amplitude among the groups. Conclusion: The HA-coated ZK60 material discs, as well as the two control materials (uncoated ZK60 and titanium discs), had minimal impact on cardiovascular function in the experimental model.
Article Details
References
2. Hiromoto S., Yamamoto A (2009) High corrosion resistance of magnesium coated with hydroxyapatite directly synthesized in an aqueous solution. Electrochim Acta, 54: 7085-7093.
3. Charan J, Kantharia ND (2013) How to calculate sample size in animal studies? J Pharmacol Pharmacother 4(4): 303-306.
4. Bộ môn Chẩn đoán chức năng (2013) Giáo trình chẩn đoán chức năng - dành cho đào tạo bậc đại học. NXB QĐND.
5. Lord B, Boswood A, Petrie A (2010) Electrocardiography of the normal domestic pet rabbit. Vet Rec 167(25): 961-965.
6. Xuan He, Ye Li, Da Zou, Haiyue Zu, Weishi Li, Yufeng Zheng (2024) An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion. Bioactive Materials 39: 456-478
7. Mark P Staigera, Alexis M Pietaka, Jerawala Huadmaia, George Dias (2006) Magnesium and its alloys as orthopedic biomaterials: A review. Biomaterials 27: 1728-1734.
Article Sidebar
