Prevalence of latent tuberculosis infection and associated factors among patients with chronic kidney disease undergoing maintenance hemodialysis

  • Nguyễn Thanh Tùng Bệnh viện Quân y 103, Học viện Quân y
  • Tạ Bá Thắng Bệnh viện Quân y 103, Học viện Quân y
  • Phạm Quốc Toản Bệnh viện Quân y 103, Học viện Quân y
  • Nguyễn Thị Thu Hà Bệnh viện Quân y 103, Học viện Quân y
  • Phan Bá Nghĩa Bệnh viện Quân y 103, Học viện Quân y
  • Phạm Thị Kim Nhung Bệnh viện Quân y 103, Học viện Quân y
  • Nguyễn Hoàng Cường Bệnh viện Quân y 103, Học viện Quân y
  • Lê Hữu Ý Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

Maintenance hemodialysis; latent tuberculosis infection.

Abstract

Objective: To evaluate the prevalence of latent tuberculosis infection (LTBI) several factors associated with tuberculosis infection among patients with chronic kidney disease undergoing maintenance hemodialysis (MHD). Subject and method: A descriptive cross-sectional study was conducted on 120 patients with chronic kidney disease undergoing maintenance hemodialysis at Military Hospital 103 from August 2023 to December 2025. Latent tuberculosis infection was diagnosed using the QuantiFERON-TB Gold Plus assay. Result: The prevalence of LTBI among patients undergoing maintenance hemodialysis was 27.5%. LTBI was significantly associated with male sex (OR: 2.701, 95% CI: 1.045 - 6.978), concomitant diabetes mellitus (OR: 5.968; 95% CI: 1.845 - 19.306), and viral hepatitis (HBV or HCV) (OR: 3.976, 95% CI: 1.348 - 11.727) in patients undergoing maintenance hemodialysis. Conclusion: The prevalence of LTBI among patients with chronic kidney disease undergoing maintenance hemodialysis was 27.5%. Greater attention should be paid to LTBI screening in male patients with concomitant diabetes mellitus and viral hepatitis among patients undergoing maintenance hemodialysis.

Article Details

References

1. World Health Organization (2018) Guidelines on the management of latent tuberculosis infection. Available from: WHO/CDS/TB/2018.4.
2. World Health Organization (2025) Global tuberculosis report 2025.
3. Al-Efraij K, Mota L, Lunny C et al (2015) Risk of active tuberculosis in chronic kidney disease: A systematic review and meta-analysis. Int J Tuberc Lung Dis 19(12): 1493-1499. 10.5588/ijtld.15.0081.
4. Kidney Disease (2024) Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int 105(4): 1-350.
5. Zellweger JP, Sotgiu G, Corradi M et al (2020) The diagnosis of latent tuberculosis infection (LTBI): currently available tests, future developments, and perspectives to eliminate tuberculosis (TB). Med Lav. 111(3): 170-183. 10.23749/mdl.v111i3.9983.
6. Hayuk P, Boongird S, Pornsuriyasak P et al (2022) Interferon-gamma release assays for diagnosis of latent TB infection in chronic kidney diseases and dialysis patients. Frontiers in Cellular and Infection Microbiology 12:1046373.
7. Marks GB, Nhung NV, Nguyen T et al (2018) Prevalence of latent tuberculous infection among adults in the general population of Ca Mau, Viet Nam. The International Journal of Tuberculosis and Lung Disease 22(3): 246-251.
8. Ogawa Y, Harada M, Hashimoto K et al (2021) Prevalence of latent tuberculosis infection and its risk factors in Japanese hemodialysis patients. Clinical and Experimental Nephrology 25(11): 1255-1265.
9. Xia Y, Fan Q, Zhang J et al (2024) Risk factors and prognosis for latent tuberculosis infection in dialysis patients: A retrospective cohort study at a single tertiary care center. Seminars in Dialysis Wiley Online Library.
10. Kumar NP, Babu S (2023) Impact of diabetes mellitus on immunity to latent tuberculosis infection. Frontiers in Clinical Diabetes and Healthcare 4: 1095467.
11. Zhou G, Guo X, Cai S et al (2023) Diabetes mellitus and latent tuberculosis infection: An updated meta-analysis and systematic review. BMC Infectious Diseases 23(1): 770.
12. Lương Anh Bình (2021) Thực trạng chẩn đoán và điều trị nhiễm lao tại hai tỉnh Quảng Nam, Đà Nẵng và kết quả một số giải pháp can thiệp. Luận án tiến sĩ y học cộng đồng, Đại học Y Hà Nội.
13. Ismail MB, Zarriaa N, Osman M et al (2023) Prevalence of latent tuberculosis infection among patients undergoing regular hemodialysis in disenfranchised communities: A multicenter study during COVID-19 pandemic. Medicina 59(4): 654.
14. Chen J, Hubbard A, Bagley L et al (2022) Prevalence of latent tuberculosis infection among persons with chronic hepatitis B virus infection: a systematic review and meta-analysis. Digestive Diseases and Sciences1-9.