Nghiên cứu lâm sàng đánh giá hiệu quả sử dụng exosome từ tế bào gốc trung mô dây rốn kết hợp laser trong điều trị lão hoá da

Abstract

Background: Skin aging is characterized by impaired fibroblast function, reduced collagen synthesis, and microcirculatory dysfunction. Exosomes derived from mesenchymal stem cells are considered a promising approach for improving signs of skin aging due to their ability to regulate cellular activity and promote tissue regeneration. Objective: To evaluate the safety and efficacy of exosomes in improving selected features of skin aging. Subject and method: This interventional study involved 20 participants receiving laser treatment combined with topical exosome application. Safety and efficacy were assessed using the VISIA skin analysis system and participant self-reported questionnaires. Result: No serious adverse events were observed. After treatment, significant improvements were noted in wrinkle reduction, pore size, and vascular lesions (p<0.01). Pigmentation and skin uniformity showed a trend toward improvement, although not statistically significant. Most participants reported enhanced skin brightness, smoothness, hydration, and elasticity. Conclusion: Exosomes demonstrate potential in improving signs of skin aging. However, further studies with larger sample sizes and controlled designs are needed to confirm their clinical applicability.