Đặc điểm các bó chất trắng của bệnh nhân xơ cứng rải rác trên cộng hưởng từ sức căng khuếch tán

Abstract

Objectives:To investigate microstructural alterations of major white matter tracts in patients with multiple sclerosis (MS) using 3.0 Tesla diffusion tensor imaging (DTI). Subjects and Methods: A cross-sectional study was conducted on 30 patients with multiple sclerosis and 30 healthy controls from November 2018 to June 2022. Diffusion tensor tractography was performed to evaluate major white matter tracts. Quantitative parameters included fiber number, voxel count, fractional anisotropy (FA), apparent diffusion coefficient (ADC), and fiber length. Results: Three-dimensional tractography showed no obvious abnormalities in the morphology or trajectory of the examined white matter tracts. Quantitative analysis demonstrated a trend toward reduced fiber number and voxel count in several tracts, particularly the temporo-occipital and fronto-occipital pathways, while the corticocerebellar tract showed a trend toward increased values. ADC values were generally higher across most white matter tracts, whereas FA values showed no clear differences between groups. Conclusions: DTI shows potential in reflecting microstructural alterations of white matter in patients with multiple sclerosis. However, these preliminary findings are suggestive and require further validation in studies with larger sample sizes.