ISSN: 1859 - 2872
The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for mortality in sepsis patients at 108 Military Central Hospital
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Abstract
Objective: To evaluate the prognostic value of the Neutrophil-to-Lymphocyte Ratio (NLR) for mortality in patients with sepsis. Subject and method: A short-term retrospective cohort study was conducted at 108 Military Central Hospital. A total of 101 patients diagnosed with sepsis according to Sepsis-3 criteria (from January 2024 to December 2024) were included in the analysis. Data on age, gender, blood culture results, and the NLR index (calculated from the peripheral blood count upon admission) were collected. Patients were grouped based on clinical outcomes (survivors and non-survivors). The optimal cut-off point for NLR was determined using the Youden index and Receiver Operating Characteristic (ROC) curve analysis. Result: The study enrolled 101 patients, with an overall mortality rate of 41.6% (n = 42). For predicting mortality in patients with sepsis, the Area Under the ROC Curve (AUC) for NLR was 0.894 (95% CI: 0.834-0.955, p<0.001). At the optimal cut-off point (NLR ≥ 11.39), NLR achieved a sensitivity of 97.6% and a specificity of 64.4%. The Positive Likelihood Ratio (LR+) was 2.74 and the Negative Likelihood Ratio (LR-) was 0.04. Conclusion: The NLR is a simple and readily available index that has a significant association with mortality in sepsis patients. The threshold of NLR ≥ 11.39 can serve as a supportive early warning sign, particularly when combined with other clinical scores and biomarkers.
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References
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