ISSN: 1859 - 2872
Combination of the BAP-65 score and peripheral blood eosinophil count in predicting in-hospital mortality among patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease
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Abstract
Objective: To evaluate the prognostic value of combining the BAP-65 score with peripheral blood eosinophil count in predicting in-hospital mortality among patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Subject and method: A retrospective descriptive study of patients aged ≥40 years admitted with AECOPD to the Emergency Department of 108 Military Central Hospital between 2022 and 2023. Associations between BAP-65 score and eosinophil count were analyzed. A combined predictive model with BAP-65 score and eosinophil count was developed and compared with the BAP-65 score alone for in-hospital mortality prediction. Result: A total of 227 patients hospitalized with AECOPD were included; the in-hospital mortality rate was 6.2%. Compared with survivors, non-survivors had significantly lower eosinophil counts (0.09 ± 0.10 vs 0.27 ± 0.30; p=0.001) and higher BAP-65 scores (3.1 ± 0.6 vs 2.4 ± 0.8; p=0.002). There was an association between eosinophil count and BAP-65 score categories (p=0.01). The combined model demonstrated superior discrimination for in-hospital mortality (AUC = 0.81) compared with the BAP-65 score alone (AUC = 0.74; p=0.024). Conclusion: The combination of the BAP-65 score and peripheral blood eosinophil count improved the prediction of in-hospital mortality in patients with AECOPD compared with the BAP-65 score alone.
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References
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