ISSN: 1859 - 2872
Correlation between plasma adiponectin levels and tissue expression of p-AMPKα, p-STAT3 in gastric cancer
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Abstract
Objective: This study aimed to evaluate the relationship between plasma adiponectin (APN) levels and histological expression of p-AMPKα in gastric carcinoma, and to investigate the prognostic role of p-STAT3 as a reference biomarker. Subject and method: A descriptive longitudinal study was conducted on 68 patients with gastric carcinoma who underwent curative gastrectomy. Plasma APN levels were quantified using ELISA. Tissue expression of p-AMPKα and p-STAT3 was assessed by immunohistochemistry. Results: Plasma APN levels were significantly higher in the group with weak p-AMPKα staining intensity (p=0.008), but did not differ between the p-AMPKα (-) and p-AMPKα (+) groups (p=0.834). APN levels showed no significant difference between the p-STAT3 (-) and p-STAT3 (+) groups, nor between the weak and strong p-STAT3 expression subgroups (p>0.05). In survival analysis, p-STAT3 positivity emerged as an unfavorable prognostic factor (HR = 57.562, p=0.016). Conclusion: Plasma APN levels were higher in patients with weaker p-AMPKα expression. Elevated p-STAT3 expression predicted worse postoperative survival in gastric cancer patients, whereas the prognostic roles of APN and p-AMPKα remain unclear.
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References
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