ISSN: 1859 - 2872
Case report: aspergillus infection on residual limb wound
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Abstract
Invasive cutaneous and soft-tissue aspergillosis is rare, usually confined to the superficial layers but occasionally extending into deeper tissues and internal organs, particularly in immunocompromised patients. However, it may also occur in immunocompetent individuals, especially after trauma, burns, or surgery; among these, post-surgical invasive aspergillosis (PSIA) is very uncommon and often underrecognized. This report describes a healthy female patient who developed Aspergillus sp. infection at a transfemoral amputation stump after a traffic accident. The diagnosis was confirmed by positive culture of necrotic tissue on Sabouraud dextrose agar and histopathology (H&E, PAS) demonstrating branching hyphae invading the tissue. Management included surgical debridement, split-thickness skin autografting, and systemic antifungal therapy (intravenous voriconazole for 1 week followed by oral itraconazole for 5 months). After 5 months, the stump healed with good scarring and no recurrent necrosis. This case highlights the importance of considering invasive fungal infection in contaminated wounds and combining culture and histopathology with surgical and systemic antifungal therapy.
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References
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